While ATG16L2 stabilizes ATG5 and enables ATG12–ATG5 conjugation, this endogenous dominant-negative inhibitor simultaneously displaces ATG16L1, resulting in its proteasomal degradation and a block in autophagy. Thus, collectively, our findings provide novel insights into ATG12–ATG5-ATG16L1 complex ...
1.Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma. and spring 机译:Atg5-Atg12 / Atg16L1自噬蛋白复合物在干扰素γ的抗病毒活性中的非降解作用。 Hwang S ,Maloney NS ,Bruinsma MW - Cell Host & Microbe - 2012 2.The roles of in...