In summary, three INAD mouse models show comparable changes in Glu-induced Ca 2+ signaling, but specific for neurons or astrocytes. This finding helps to identify pathways altered during INAD and highlights non-canonical VIA iPLA 2 functions, like regulation of cellular Ca 2+ fluxes by ...
Transcriptomic signatures of astrocytes from AD mouse models were obtained from recent studies [29,32]. Mouse to human gene conversions were conducted using homology data available through the Mouse Genome Database [5]. snRNAseq of mouse brains identified a cluster of astrocytes that was enriched ...
Though different terms, including astrocyte activation and astrogliosis have been used interchangeably with astrocyte “reactivity”, the phenotype change found in AD and other forms of neurodegeneration is probably best described as a reaction to pathological factors (Escartin et al., 2021). In AD, ...
Despite their roles in homeostasis, following noxious stimulation and nerve injury, the phenotype, functions, and gene expression of astrocytes can elicit a significant change in the form of reactive astrogliosis [72]. The conversion of astrocytes from normal to reactive phenotypes encompasses a variety...
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Most importantly, bilobalide reduces amyloid and inflammation in AD mouse brain. Taken together, the protective effects of bilobalide in in vitro cultures were fully recapitulated in in vivo AD mouse model. Our study supports that bilobalide has therapeutic potential for AD treatment....
how it was generated, which cells express the transgenes, and the effect of its genetic background on Aβ pathology. Subsequently, to determine whether modifying reactive astrocytes in AD could influence pathogenesis and cognition, we review studies using this mouse model in which interventions were...
163, 164 No change in the number of astroglial profiles was found in the primary visual cortex of old rhesus monkeys165; similarly, the quantity of astrocytes in the human neocortex did not change with age.166 Significant increase in GFAP expression and astroglial hypertrophy was detected in the...
A short-term exposure to ketamine (30 min) thus resulted in a visible change in astroglial membrane structure (Lasic et al., 2019) as suggested by increased D4-positive domain density (Fig. 3), whereas results gathered from earlier in vitro studies demonstrated that soluble and contact-...
Given our observation that astrocytes displayed high rates of mitochondria transfer to mouse models of GBM and their previously described interconnected nature with GBM in vivo32, we focused our subsequent studies on this glial cell population. We began by coculturing either mito-mCherry or mitoDsRe...