Cell LineAnimalsMice, Inbred DBAMiceBucladesineCell DifferentiationTime FactorsDisaggregated cells of newborn DBA/1J mouse neopallium were grown in colony cultures, and colonies of cells at various stages of differentiation along the astrocyte cell lineage were examined after 3 days, 1, 2 and 4 ...
TheEScellsofD3linecouldmaintaintheabilityofdifferentiatingintocellularderivationsofallthree primarygermlayersaftercontinuouspassageculture.Attheendoftwo—stageofinducingprocess,23.24-3.5 neurospheresperplateformedinastrocyte—inducedgroupandonly0.8±0.3perplateinthecontrolgroup ...
Sox9/Sox10 and in situ hybridization forPlp1(Supplementary Figs.2D–F, 3D–F). We found that the inversion of the cassettes did not reduce the percentages of EGFP-positive neurons and oligodendrocytes (pPB-inverted-Gfa2-EGFP; neuron, 13.4 ± 4.1%; astrocyte, 73.3 ± 3.5%; ol...
(that is, convergence) and distinct cell states could share a lineage (that is, divergence) (Fig.2b). To explore these possibilities, we compared hierarchies constructed from transcriptome information and hierarchies constructed from lineage coupling correlations (Fig.2c). Seven astrocyte clusters ...
别名Astrocyte derived trophic factor, Astrocyte derived trophic factor 1, Astrocyte-derived trophic factor, Atf, ATF 1, ATF 2, ATF1, ATF2, gdnf, GDNF_HUMAN, Glial cell derived neurotrophic factor, Glial Cell Line Derived Neurotrophic Factor, Glial cell line-derived neurotrophic factor ...
neuronal and SY5Y neuroblastoma cell cultures treated with 10 μM HN2, whereas cell loss was similar to controls in comparably treated astrocyte cultures. ... GE Kisby,N Springer,PS Spencer - 《Journal of Applied Toxicology》 被引量: 45发表: 2000年 l‐DOPA and glia‐conditioned medium have ...
Although many glial cell types did not show strong tissue region-specific distribution (Fig.3b) as expected11,26, we observed a few exceptions. First, our results confirmed previous reports of region-specific enrichment of astrocyte subtypes1, including those in the telencephalon (AC_2,3), non...
28 In line with this, in a mouse model where Apoe is specifically knocked out in astrocytes, microglia show a downregulation of DAM markers.30 It should be noted that although our analysis did not identify disruptions in the microglia-to-astrocyte PIG signaling pairs that are present in both ...
White dashed line demarcates transition from white to gray matter. Scale bar = 50 μm. h, Quantification of Timp1 + /Slc1a3 + astrocyte numbers using RNAScope in corpus callosum. A cell is identified as Timp1 + if it expresses ≥20 dots/cell. P-value calculated with...
et al. Evidence for aberrant astrocyte hemichannel activity in juvenile neuronal ceroid lipofuscinosis (JNCL). PLoS One 9, e95023 (2014). PubMed PubMed Central Google Scholar Sondhi, D. et al. Partial correction of the CNS lysosomal storage defect in a mouse model of juvenile neuronal ...