We hypothesized that exposure to saturated fatty acids can compromise astrocyte viability and mitochondrial function. The C6 (astrocytes) cell line was treated with palmitate or stearate (200 M and 400 M) for 6 h. Cell viability, morphology, inflammatory markers, and oxidative stress w...
This study sought to determine the protective effect of resveratrol against hydrogen peroxide (H2O2)-induced cytotoxicity in C6 astrocyte cell line, an astrocytic lineage, on neurochemical parameters and their cellular and biochemical mechanisms. H2O2exposure increased oxidative-nitrosative stress, iNOS ...
exacerbates mitochondrial failure and causes cellular damage.This study sought to determine whether prevention of mitochondrial dysfunction and the maintenance of cellular redox status by resveratrol contribute to its protective action toward ammonia toxicity.C6 astrocyte cell line was pre-incubated in the ...
关键词: Ruthenium(III N, N-Dimethylglycine Astrocytoma Astrocyte Tumor DOI: 10.1016/j.jinorgbio.2004.10.007 被引量: 43 年份: 2004 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 全文购买 Elsevier 国家科技图书文献中心 (权威机构) Semantic Scholar dx.doi.org Ingenta 查看更多 ...
These cells undergo differentiation and are shown to propagate calcium ion waves, called astrocyte excitability56, in the brain as well as under in vitro conditions57,58. Treatment with dibutyryl cAMP59,60 or taxol54 enabled these cells to differentiate, giving typical neuronal morphology. In our ...
Growth kinetics, cell shape, and the cytoskeleton of primary astrocyte cultures. J Nerochem 1984; 42:175–84. Article CAS Google Scholar Wolfe RA, Sato GH, Meclure DB . Continuous culture of rat C6 glioma cells in serum-free medium. J Cell Biol 1980; 87:434–41. Article CAS Google ...
The results indicated that the malignant proliferation of C6 cells slowed down and the characteristics of normal astrocyte cells emerged. Gene expression changed rapidly and robustly in cholera toxin- induced differentiation C6 cells displayed a robust transcription response, and the expression of many ...
This chapter describes signaling pathways stimulated by the P2Y2 nucleotide receptor (P2Y2R), that regulate cellular processes dependent on actin cytoskeleton dynamics in glioma C6 cells. P2Y2R coupled with G-proteins, in response to ATP or UTP, regulate
In our study, it was demonstrated that in an astrocyte cell line from rats (C6) which received short-term treatment with palmitate (C16:0), there was a decrease in cell viability in these cells, indicating a cytotoxic effect of palmitate. Similar results were found in an in vitro model of...
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue. Curr. Drug Targets 2013, 14, 1225–1236. [Google Scholar] [CrossRef] [Green Version] Zink, M.; Vollmayr, B.; Gebicke-Haerter, P.J.; Henn, F.A. Reduced expression of glutamate transporters v...