Astrocyte Ca2 dysregulation and neurovascular coupling deficits in a diet‐based mouse model of small cerebral vessel diseasedoi:10.1002/alz.080450Weiss, Blaine E.Sompol, Pradoldej MGant, John CLin, Ruei‐LungNelson, Peter TThibault, Olivier...
人类的星形胶质细胞比啮齿类动物的大20多倍,形成的突触数量是啮齿类动物的10多倍。 自1990年代中期的研究表明,星形胶质细胞受到刺激时可在细胞间远距离传播Ca2+波,并且,类似于神经元,以Ca2+依赖的方式释放神经递质(称为胶质递质 (Gliotransmitter))。数据表明,星形胶质细胞还会通过钙离子依赖的路径释放谷氨酸,向神经元...
c), which was absent in a control condition in which the GCaMP was illuminated with isosbestic excitation light (405 nm) (Fig.2b, d)45,46. The astrocyte Ca2+activity was high during both wakefulness and rapid-eye-movement (REM) sleep and low during non-REM (NREM...
fADPSEN1 (ΔE9)AstrocyteIncreased Aβ production; altered cytokine release; dysregulated Ca2+homeostasis; increased oxidative stress; reduced lactate secretion; compromised neuronal supportive function.Oksanen et al., 2017 sADAPOE (E4/E4)AstrocyteReduced ApoE level; accumulated cholesterol; impaired Aβ...
6). Fundamental differences between astrocytes and neurons were identified; for example, proteins related to Ca2+-dependent vesicular γ-aminobutyric acid release were abundant in neurons but largely absent in astrocytes28 (Fig. 1h and Extended Data Fig. 5f). Conversely, proteins related to lipid ...
134Citations 7Altmetric Explore all metrics Abstract Astrocytes have long been considered as just providing trophic support for neurons in the central nervous system, but recently several studies have highlighted their importance in many functions such as neurotransmission, metabolite and electrolyte homeosta...
Reproducibility and comparability of models for astrocyte Ca2+ excitability (Manninen et al 2017) astrocyte oscillations-signaling-pathways-calcium-dynamics python-web-link-to-model Updated Dec 23, 2023 ModelDBRepository / 267696 Star 0 Code Issues Pull requests Glial voltage dynamics driven by ...
Astrocyte Intracellular Ca2+and TrkB Signaling in the Hippocampus Could Be Involved in the Beneficial Behavioral Effects of Antidepressant Treatment Astrocyte Intracellular Ca2+and TrkB Signaling in the Hippocampus Could Be Involved in the Beneficial Behavioral Effects of Antidepressant Treatment... FR ...
As non-excitable cells, astrocyte activity is primarily regulated by elevations in intracellular Ca2+concentration ([Ca2+]i). Stimulation of neurotransmitter or growth factor receptors on astrocytes mobilizes Ca2+from intracellular stores, eliciting Ca2+signals characterized by waves or oscillations13. Thes...
Ca2 transients in astrocyte fine processes occur via Ca2 influx in the adult mouse hippocampus doi:10.1002/glia.23042GliaRungta, Ravi L.Bernier, Louis‐PhilippeDissing‐Olesen, LasseGroten, Christopher J.LeDue, Jeffrey M.Ko, RebeccaDrissler, SibylMacVicar, Brian A....