After focal transient ischemia, an increase of the immunolabeling is detected on astrocytes in periinfarct areas. This AQP9 distribution study in mouse brain suggests a role of AQP9 in water homeostasis in the central nervous system. Furthermore, the overexpression of AQP9 on astrocytes ...
How this transition is affected by time and sex, its heterogeneity at the single-cell level and how sub-states are spatially distributed in the brain remains unclear. In this study, we investigated transcriptome changes of mouse cortical astrocytes after an acute inflammatory stimulus using the ...
2004 . Neuronal and astrocyte expression of nicotinic receptor subunit beta4 in the adult mouse brain . J Comp Neurol 468 : 322 – 333 ... LC Gahring,K Persiyanov,SW Rogers - 《Journal of Comparative Neurology》 被引量: 121发表: 2004年 Neuronal nicotinic receptor alpha 6 subunit mRNA is...
Interfering with astrocyte NMDAR or GluN2C NMDAR activity reduces the range of presynaptic strength distribution specifically in the 展开 关键词: GluN2C NMDA receptors astrocytes basal synaptic strength hippocampus mouse neuroscience stratum radiatum ...
[23]. This kind of reactive astrocytes seems to be abundant in post-mortem AD brain. In mouse primary hippocampal cultures, astrocytes internalized oligomeric tau, which was followed by reduced gliotransmitter release, especially ATP [24]. The reduced ATP release from astrocytes reduced the ...
to visualize infected cells (same total viral titer). Depending on the experiment, bilateral injections of the same viruses were performed and controls were generated in different animals. Alternatively, the contralateral brain region was injected with the control virus and data analyzed with paired...
Recent single-cell RNA sequencing performed in the mouse identified at least seven distinct astrocyte types with regionally restricted distribution (Zeisel et al., 2018) and five transcriptomically distinct astrocyte subtypes in cortex and hippocampus (Batiuk et al., 2020). Show abstract Astrocyte ...
to control chromatin accessibility. The number of ACLY+p300+memory astrocytes is increased in acute and chronic EAE models, and their genetic inactivation ameliorated EAE. We also detected the pro-inflammatory memory phenotype in human astrocytes in vitro; single-cell RNA sequencing and immunohistochemis...
Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to maintain brain iron homeostasis. However, th
The first study combining scRNAseq to characterize reactive astrocytes with targeted molecular manipulations demonstrates, in a mouse model of MS, that reactive astrocytes are molecularly and functionally heterogeneous, depending on brain area and disease stage. Article CAS PubMed PubMed Central Google ...