Genc S, Kurnaz IA, Ozilgen M. Astrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions- -in silico study supported by in vitro expression data. BMC Syst Biol 2011; 5: 162 [PMID: 21995951 DOI: 10.1186/1752-0509-5-162]...
Astrocytes play a key role in the maintenance of synaptic transmission by producing L‐lactate via the astrocyte‐neuron lactate shuttle (ANLS). Astrocyte activation in the spinal cord is involved in the expression of neuropathic pain. We investigated the role of the ANLS in the spinal cord on...
An operational model, the `astrocyte- neuron lactate shuttle', is supported experimentally by a large body of evidence, which provides a molecular and ... Magistretti,Pierre,J. - 《Journal of Experimental Biology》 被引量: 606发表: 2006年 Inhibition of monocarboxylate transporter 2 in the retro...
This energy transfer process is enabled by an astrocyte-to-neuron lactate shuttle (Pellerin and Magistretti, 1994). In line with the notion that seizure-induced lactate formation promotes epileptic seizures, lactate dehydrogenase inhibitors, such as the FDA-approved drug stiripentol, provide potent ...
Astrocytes have long been considered as just providing trophic support for neurons in the central nervous system, but recently several studies have highlighted their importance in many functions such as neurotransmission, metabolite and electrolyte homeostasis, cell signaling, inflammation, and synapse modula...
Kurnaz, M. Ozilgen, Astrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions--in silico study supported by in vitro expression data, BMC Syst. Biol. 5 (2011) 162.Seda, Genc,Isil A,etc.Astrocyte-neuron lactate shuttle may boost more ATP supply to ...
Functional astrocyte-neuron lactate shuttle in a human stem cell-derived neuronal network. J Cereb Blood Flow Metab 2013; 33: 1386-1393.Tarczyluk MA, Nagel DA, O'Neil JD (2013) Functional astrocyte-neuron lactate shuttle in a human stem cell-derived neuronal network. J Cereb Blood Flow ...
We hypothesized that astrocytes-neuronlactate shuttle (ANLS) activation could be another potential underpinning mechanism that complements collateral flow in the protection process. Supporting our hypothesis, using functional imaging, pharmacological treatments, and postmortem histology, we showed that ANLS ...
Astrocytes play an important role in cognitive function, and homeostasis of the astrocyte-neuron lactate shuttle (ANLS) system is essential for maintaining cognitive functions. Aquaporin-4 (AQP-4) is a water channel expressed in astrocytes and has been shown to be associated with ...
The astrocyte--neuron lactate shuttle: a debated but still valuable hypothesis for brain imaging. J Cereb Blood Flow Metab. 2005; 25 :1394–1399. [ PubMed ]Bonvento G, Herard AS, Voutsinos-Porche B (2005) The astrocyte–neuron lactate shuttle: a debated but still valuable hypothesis for ...