Lactate shuttles in nature 来自 NCBI 喜欢 0 阅读量: 129 作者: GA Brooks 摘要: Once thought to be the consequence of oxygen lack in contracting skeletal muscle, the glycolytic product lactate is formed and utilized continuously under fully aerobic conditions. "Cell-cell" and "intracellular lactate...
in Youmans Neurological Surgery (ed. Winn, H. R.) 123–146 (Elsevier Saunders, Philadelphia, 2011). Brooks, G. A. Lactate shuttles in nature. Biochem. Soc. Trans. 30, 258–264 (2002). Article CAS PubMed Google Scholar Gladden, L. B. Lactate metabolism: a new paradigm for the ...
G.A. Brooks Lactate shuttles in Nature Biochem. Soc. Trans., 30 (2) (Apr. 2002), pp. 258-264, 10.1042/BST0300258 View in ScopusGoogle Scholar [20] Y. Fu, et al. The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy Onco...
In the 1920s, Otto Warburg observed for the first time that tumors consume more glucose than surrounding normal tissue, leading him to propose the phenomenon of aerobic glycolysis, wherein glucose can be fermented to produce lactate instead of carbon dioxide, even in the presence of oxygen; this...
Draoui N, Feron O. Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech. 2011;4:727–32. ArticleCASPubMedPubMed CentralGoogle Scholar Liu H, Tu L, Zhou Y, Dang Z, Wang L, Du J, et al. Improved bioavailability and Antitumor Effect of Do...
Lactate (La−) has long been at the center of controversy in research, clinical, and athletic settings. Since its discovery in 1780, La− has oft
Additional information Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions
Lactate shuttles in Nature. Biochem. Soc. Trans. 2002, 30, 258–264. [Google Scholar] [CrossRef] Nalbandian, M.; Radak, Z.; Takeda, M. Lactate Metabolism and Satellite Cell Fate. Front. Physiol. 2020, 11, 610983. [Google Scholar] [CrossRef] Everse, J.; Kaplan, N.O. Lactate ...
we now know that Organ–Organ, Cell–Cell, and Intracellular Lactate Shuttles operate continuously. By means of lactate shuttling, fuel-energy substrates can be exchanged between producer (driver) cells, such as those in skeletal muscle, and consumer (recipient) cells, such as those in the brain...
Investigations of such cell-to-cell l-lactate shuttles would be facilitated by a genetically encoded fluorescent biosensor that would enable high resolution spatially and temporally resolved imaging of the extracellular l-lactate concentration. Genetically encoded fluorescent biosensors are powerful tools for...