Astrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions--in silico study supported by in vitro expression data. BMC Syst Biol [Internet]. BioMed Central Ltd; 2011 Jan [cited 2013 Dec 13];5(1):162. Available from: http://www.pubmedcentral.nih.gov...
Astrocytes play a key role in the maintenance of synaptic transmission by producing L‐lactate via the astrocyte‐neuron lactate shuttle (ANLS). Astrocyte activation in the spinal cord is involved in the expression of neuropathic pain. We investigated the role of the ANLS in the spinal cord on...
英文: Thrombospondins are astrocyte-secreted proteins that promote synaptogenesis中文: 星形胶质细胞分泌血小板反应蛋白(TSP)促进神经突触形成 英文: Primary cultivation of SD rat cerebral astrocyte中文: SD大鼠星形胶质细胞的原代培养 英文: Astrocyte-neuron lactate shuttle for energy supply in brain中文: 脑部...
This article discusses the present version of the astrocyte-neuron lactate shuttle model. The model consists of two components, the enhancement of aerobic glycolysis in astrocytes and the oxidation in neurons of lactate. Astrocytes are more affected with the combination of glycolysis and glycogenolysis...
After entering the neuronal compartment, lactate is converted into pyruvate by lactate dehydrogenase type 1; pyruvate enters the citric acid cycle and is utilized to produce energy. This process is generally known as ‘astrocyte–neuron lactate shuttle’ and represents a universal mechanism for ...
The astrocyte-neuron lactate shuttle model sets forth the importance of astrocytes in providing lactate for the metabolic supply of neurons under intense activity. Lactate also plays a role as a signaling molecule and has been recently studied regarding its antidepressant activity. This review discusses...
et al. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev. Neurosci. 20, 291–299 (1998). 55. Rancillac, A., Geoffroy, H. & Rossier, J. Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimer's disease. Curr. Alzheimer Res. ...
Single cell RNA-sequencing of the AstTau neuron-asteroid tau assembloid model reveals excitatory neuron inflammatory signatures and an astrocytic heat shock response similar to that occurring in the brains of individuals with tauopathies, which can be ameliorated with a neuroprotective HSP90 inhibitor. ...
Astrocytes have long been considered as just providing trophic support for neurons in the central nervous system, but recently several studies have highlighted their importance in many functions such as neurotransmission, metabolite and electrolyte homeostasis, cell signaling, inflammation, and synapse modula...
Through this sequence of metabolic reactions lactate, formed in astrocytes, becomes a major energy source to sustain the energy demands of hyperactive neuronal networks. This energy transfer process is enabled by an astrocyte-to-neuron lactate shuttle (Pellerin and Magistretti, 1994). In line with ...