to-neuron(AtN)conversion is a new approach for generating newborn neurons by directly converting endogenous astrocytes into neurons.The BrdU-labeling strategy has been used to trace astrocyte-converted neurons,but whether BrdU has any effect on the AtN conversion is unknown.Here,while conducting a ...
et al. Revisiting astrocyte to neuron conversion with lineage tracing in vivo. Cell 184, 5465–5481.e5416 (2021). Article CAS Google Scholar Bocchi, R., Masserdotti, G. & Götz, M. Direct neuronal reprogramming: fast forward from new concepts toward therapeutic approaches. Neuron 110, ...
www.nature.com/scientificreports OPEN Astrocyte-to-neuron intercellular prion transfer is mediated by cell- cell contact received: 20 August 2015 accepted: 07 January 2016 Published: 09 February 2016 Guiliana Soraya Victoria, Alexander Arkhipenko, Seng Zhu, Sylvie Syan & Chiara Zurzolo...
Here, we demonstrate that NeuroD1-mediated in situ astrocyte-to-neuron conversion can regenerate a large number of functional new neurons after ischemic injury. Specifically, using NeuroD1 adeno-associated virus (AAV)-based gene therapy, we were able to regenerate one third of the total lost ...
Revisiting astrocyte to neuron conversion with lineage tracing in vivo. Cell. 2021;184:5465–e54815416. Article CAS PubMed PubMed Central Google Scholar Li J, Ye L, Wang X, Liu J, Wang Y, Zhou Y, Ho W. (-)-Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory ...
Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex Regenerating functional new neurons in the adult mammalian central nervous system has been proven to be very challenging due to the inability of neurons to... Z Xiang,L Xu,M Liu,... - 《中国神经再生研究(英文版)》...
18.The information from the active neuron is thus encoded as a calcium signal in the astrocyte. 来自活性神经元的信息由此编码为星细胞里的钙信号. 19.Volterra believed that some astrocytes were capable of the latter. 20.To determine how C420R might drive seizures, the authors expressed PIK3CA var...
One of the functional consequences of neuron-to-astrocyte signaling might be the neuronal control of microcirculation using astrocytes as a mediator.doi:... CG Schipke,H Kettenmann - 《Glia》 被引量: 140发表: 2010年 Central role of neuron-to-astrocyte signalling in the control of brain microcir...
The later groups of genes were used to assess the degree of astro- cyte activation. The panel also included 8 microglia-, 10 neuron-, and 2 oligodendrocyte-specific genes along with 10 housekeeping genes. On average, the designed probes were positive for 99.9% of the samples, with 98.8% ...
Western blotting of the β5-integrin-negative cell subpopulation (astro- cyte-free neurons, as revealed by neuron-specific βIII-tubulin) demonstrated that neurons accounted for the MG132- mediated increase in Nrf2 protein (Supplementary Figure 4d). Cell Death and Differentiation 1880 NMDAR activity...