to-neuron(AtN)conversion is a new approach for generating newborn neurons by directly converting endogenous astrocytes into neurons.The BrdU-labeling strategy has been used to trace astrocyte-converted neurons,but whether BrdU has any effect on the AtN conversion is unknown.Here,while conducting a ...
et al. Revisiting astrocyte to neuron conversion with lineage tracing in vivo. Cell 184, 5465–5481.e5416 (2021). Article CAS Google Scholar Bocchi, R., Masserdotti, G. & Götz, M. Direct neuronal reprogramming: fast forward from new concepts toward therapeutic approaches. Neuron 110, ...
www.nature.com/scientificreports OPEN Astrocyte-to-neuron intercellular prion transfer is mediated by cell- cell contact received: 20 August 2015 accepted: 07 January 2016 Published: 09 February 2016 Guiliana Soraya Victoria, Alexander Arkhipenko, Seng Zhu, Sylvie Syan & Chiara Zurzolo...
A new study used NeuroD1 AAV-based in situ astrocyte-to-neuron conversion to regenerate one-third of the neurons lost due to ischemic injury, as demonstrated by RNA sequencing and immunostaining at the mRNA and protein levels (Chen et al., 2020). Two months after NeuroD1 expression, brain...
[62]. However, this ongoing debate still leaves several outstanding questions to be addressed: 1. What is the determinant factor for the observed therapeutic effects following PTBP1 suppression if it was not directly related to astrocyte-to-neuron conversion? Pathway investigations are warranted as...
Central role of neuron-to-astrocyte signalling in the control of brain microcirculation , Rosengarten B, Hossmann KA, Pozzan T, Carmignoto G (2003) Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation... G Carmignoto - 《Neurophrmacology》 被引量: 0发表...
Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex Regenerating functional new neurons in the adult mammalian central nervous system has been proven to be very challenging due to the inability of neurons to... Z Xiang,L Xu,M Liu,... - 《中国神经再生研究(英文版)》...
et al. Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP. Sci. Rep. 7, 44507 (2017). Article CAS PubMed PubMed Central Google Scholar Kim, J. et al. Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch ...
Astrocytes, from brain glue to communication elements: the revolution continues. Nature Rev. Neurosci. 6, 626–640 (2005). Article CAS Google Scholar Zonta, M. et al. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature Neurosci. 6, 43–50 (2003...
Molecular perturbation of cholesterol biosynthesis and efflux in astrocytes caused similarly altered astrocyte–neuron cross talk, whereas enhancement of glial SREBP2 and ABCA1 function reversed the aspects of neuronal dysfunction in HD. These findings indicate that astrocyte-mediated cholesterol homeostasis ...