Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts.Metformin is a widely-used treatment for type 2 diabetes and is reported to extend health and lifespan as a caloric restriction (CR) mimetic. Although the benefits of metformin are well documented, the impact of...
We demonstrate that activator protein 1 (AP-1) 'pioneers' the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. Together, our findings enabled us to manipulate the senescence phenotype ...
We demonstrate that activator protein 1 (AP-1) ‘pioneers’ the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. Together, our findings enabled us to manipulate the senescence phenotype ...
The transcription factor AP-1 is activated in response to an incredible array of stimuli, including mitogenic growth factors, inflammatory cytokines, growth factors of the TGF-β family, UV and ionizing irradiation, cellular stress, antigen binding, and neoplastic transformation. In this review, I ...
Estrogen receptor α (ERα) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERα can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interactions ...
Signaling via activator protein-1 (AP-1) transcription factors can control a wide range of cellular processes, including proliferation, differentiation, migration, survival or death. In turn, deregulation of the AP-1 pathway has been implicated in several types of pathological conditions, such as de...
Transcription Factor AP-1 Basic informationMore.. Product Name:Transcription Factor AP-1 Synonyms:Transcription Factor AP-1;Activator protein 1;ANTI-PHOSPHO-CJUN(S63) antibody produced in rabbit;JUN;Proto-oncogene c-Jun;V-jun avian sarcoma virus 17 oncogene homolog ...
We have examined the regulation of the AP-1 transcription complex in the IL-1-responsive murine T cell thymoma cell line EL-4 6.1 C10. Our results demonstrate that AP-1-mediated gene expression in T cells may be regulated by several signaling pathways and factors, including IL-1, protein ...
The best described function of the adaptor complex-1 (AP-1) is to participate in the budding of clathrin-coated vesicles from the -Golgi network and endosomes. Here, we show that AP-1 is also localized to phagocytic cups in murine macrophages as well as in amoebae. AP-1 is recruited to...
aThus transcription factor, AP-1 can be considered as potential therapeutic targets for cervical cancer 正在翻译,请等待...[translate] a管理下屬 Manages the subordinate[translate] ashe is my sinthe massthe dawn 她是我的sinthe massthe黎明[translate] ...