Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts Zoe E. Gillespie, Chenxuan Wang, Flaviu Vadan, Topaza Y. Yu, Juan Ausió, Anthony Kusalik & Christopher H. Eskiw Scientific Reports volume 9, Article number: 5369 (2019) Cite this article 6419...
We demonstrate that activator protein 1 (AP-1) ‘pioneers’ the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. Together, our findings enabled us to manipulate the senescence phenotype ...
Most critically, our screen identifies FOSL1 and JUN, two subunits of the AP-1 transcription factor within this network, as the most significant hits. Mechanistically, we demonstrate thatcis-regulatory elements exhibiting altered chromatin accessibility in the resistant state are enriched for cognate ...
292Alterations of the cytokine communication network after irradiation: Example of TGF-β1 and AP-1 transcription factor in irradiated skin cellsenterprise groupfinancemoduleinformatizationAccreditation standards have been developed for BS programs in Information Systems and have been widely reviewed. The ...
The nuclear transcription factor AP-1, composed of dimers of Fos and Jun proteins, has been linked to a startling breadth of cellular events including cell transformation, proliferation, differentiation and apoptosis. AP-1 is often portrayed as a general, nuclear decision-maker that determines life...
Transcription Factor AP-1 Basic information More.. Product Name: Transcription Factor AP-1 Synonyms: ANTI-PHOSPHO-CJUN(S63) antibody produced in rabbit;Transcription Factor AP-1;Activator protein 1;V-jun avian sarcoma virus 17 oncogene homolog;JUN;Proto-oncogene c-Jun CAS: MF: MW: 0 EINECS...
Activating protein 1 (AP-1) is a transcription factor composed of several protein families, Jun proteins and Fos proteins are the components of AP-1. AP-1
Because the transcription factor AP-1 is important in the process of tumor promotion, the inhibitory effect of these polyphenols on AP-1 activation may further explain the anti–tumor promotion action of these tea constituents. Mol. Carcinog. 28:148–155, 2000. © 2000 Wiley-Liss, Inc. ...
In response to PH, the DNA-binding activity of the dimeric transcription factor AP-1, composed of the products of the Jun and Fos families of genes, is rapidly induced (Heim et al. 1997). Several reports have demonstrated the requirement for c-Jun in hepatocyte survival and proliferation. ...
In addition, the treatment we proposed to block the expression of the transcription factor AP-1 was successful in reducing the inflammatory process by decreasing the levels of proinflammatory cytokines, an effect observed as early as 4 weeks after the initial MCT injection. Moreover, this decrease...