Metformin is a widely-used treatment for type 2 diabetes and is reported to extend health and lifespan as a caloric restriction (CR) mimetic. Although the benefits of metformin are well documented, the impact of this compound on the function and organiza
We demonstrate that activator protein 1 (AP-1) ‘pioneers’ the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. Together, our findings enabled us to manipulate the senescence phenotype ...
Most critically, our screen identifies FOSL1 and JUN, two subunits of the AP-1 transcription factor within this network, as the most significant hits. Mechanistically, we demonstrate thatcis-regulatory elements exhibiting altered chromatin accessibility in the resistant state are enriched for cognate ...
292Alterations of the cytokine communication network after irradiation: Example of TGF-β1 and AP-1 transcription factor in irradiated skin cellsenterprise groupfinancemoduleinformatizationAccreditation standards have been developed for BS programs in Information Systems and have been widely reviewed. The ...
The nuclear transcription factor AP-1, composed of dimers of Fos and Jun proteins, has been linked to a startling breadth of cellular events including cell transformation, proliferation, differentiation and apoptosis. AP-1 is often portrayed as a general, nuclear decision-maker that determines life...
Transcription Factor AP-1 Basic information More.. Product Name: Transcription Factor AP-1 Synonyms: ANTI-PHOSPHO-CJUN(S63) antibody produced in rabbit;Transcription Factor AP-1;Activator protein 1;V-jun avian sarcoma virus 17 oncogene homolog;JUN;Proto-oncogene c-Jun CAS: MF: MW: 0 EINECS...
Activating protein 1 (AP-1) is a transcription factor composed of several protein families, Jun proteins and Fos proteins are the components of AP-1. AP-1
Because the transcription factor AP-1 is important in the process of tumor promotion, the inhibitory effect of these polyphenols on AP-1 activation may further explain the anti–tumor promotion action of these tea constituents. Mol. Carcinog. 28:148–155, 2000. © 2000 Wiley-Liss, Inc. ...
The AP-1 transcription factor c-Jun is a key regulator of hepatocyte proliferation. Mice lacking c-Jun in the liver (c-jun li*) display impaired liver regeneration after partial hepatectomy (PH). This phenotype correlates with increased protein levels of the cdk-inhibitor p21 in the liver. We...
Our findings, for the first time, demonstrate that AP2 is an important transcription factor driving USP22 gene expression, promoting the progression of NSCLC in part by enhancing USP22 expression, which will further facilitate the understanding of the USP22 network and the targeted treatment of ...