Here, we combine multiplexed transcriptional and protein measurements at population and single-cell levels with multivariate statistical modeling to show that the state of AP-1 transcription factor network plays a unifying role in explaining diverse patterns of plasticity in melanoma. We find that a ...
We demonstrate that activator protein 1 (AP-1) ‘pioneers’ the senescence enhancer landscape and defines the organizational principles of the transcription factor network that drives the transcriptional programme of senescent cells. Together, our findings enabled us to manipulate the senescence phenotype ...
Metformin is a widely-used treatment for type 2 diabetes and is reported to extend health and lifespan as a caloric restriction (CR) mimetic. Although the benefits of metformin are well documented, the impact of this compound on the function and organiza
Using ChIP-seq, we demonstrate that the cistrome for the AP-1 transcription factor c-Jun is comprised of 13,800 binding regions in TNFα-stimulated TNBC cells. In addition, we show that c-Jun regulates nearly a third of the TNFα-regulated transcriptome. Interestingly, high expression level ...
Estrogen receptor α (ERα) is a ligand-dependent transcription factor that plays an important role in breast cancer. Estrogen-dependent gene regulation by ERα can be mediated by interaction with other DNA-binding proteins, such as activator protein-1 (AP-1). The nature of such interactions ...
Transcription Factor AP-1 Basic information More.. Product Name: Transcription Factor AP-1 Synonyms: Transcription Factor AP-1;Activator protein 1;ANTI-PHOSPHO-CJUN(S63) antibody produced in rabbit;JUN;Proto-oncogene c-Jun;V-jun avian sarcoma virus 17 oncogene homolog CAS: MF: MW: 0 EINECS...
The underlined part is the enzyme gene that AP2/ERF transcription factor major regulation,the transcription factor is in the box,same as below; AATC- acetyl coenzyme A acyltransferase DXPS-1-deoxy-D-xylulose-5-phosphate synthase IPP-isopentenyl pyrophosphate DMAPP-dimethylallyl pyrophosphate FPP-farn...
We have examined the regulation of the AP-1 transcription complex in the IL-1-responsive murine T cell thymoma cell line EL-4 6.1 C10. Our results demonstrate that AP-1-mediated gene expression in T cells may be regulated by several signaling pathways and factors, including IL-1, protein ...
1. Introduction Signaling via activator protein-1 (AP-1) transcription factors can control a wide range of cellular processes, including proliferation, differentiation, migration, survival or death. In turn, deregulation of the AP-1 pathway has been implicated in several types of pathological conditio...
AP-1 can exert its oncogenic or anti-oncogenic effects by regulating genes involved in cell proliferation, differentiation, apoptosis, angiogenesis and tumour invasion. AP-1 might be a good target for anticancer therapy. Abstract The AP-1 transcription factor is a dimeric complex that contains membe...