The activator protein-1 (AP-1) transcription factor family has been implicated in a multitude of physiologic processes and tumorigenesis; however, its role in MM is largely unknown. Here we demonstrate specific and rapid induction of the AP-1 family member JunB in MM cells when co-cultured ...
growth factor receptorsThis issue attempts to give a 'state of the art' overview of the AP-1 transcription factor family, a fundamental class of transcriptional regulators. The AP-1 family consists of several bZIP (basic region leucine zipper) domain proteins, the Jun, the Fos, and the ATF ...
AP-1 family transcription factor is a dimeric protein complex composed of heterodimers between Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra-1, and Fra-2), and ATF family gene products. From:Differentiation,2011 Also in subject areas: ...
The activator protein-1 (AP-1) proteins are a collection of transcription factors characterized by the presence of a basic leucine zipper (bZip) domain (Fig.1a). This family of proteins was first described in the 1980s whenv-Fosandv-Junwere identified as the oncogenic factors associated with ...
AP-1 proteins are a versatile family of dimeric transcription factors The activator protein-1 (AP-1) proteins are a collection of transcription factors characterized by the presence of a basic leucine zipper (bZip) domain (Fig.1a). This family of proteins was first described in the 1980s when...
Particularly, the level of expression of members of the AP-1 transcription factor family, such as c-Jun and c-Fos, has been shown to increase shortly after the exposure of cells to either mitogens or UV light (23, 60, 61). However, in order to exert its transcriptional activation ...
We focus on the role of the transcription factor AP-1 to both induce the expression of genes that function as invasion effectors and repress other genes that function as invasion suppressors. This identifies AP-1 as a critical regulator of a complex program of gene expression that defines the ...
The AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS, ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but recent studies have challenged this view — some AP-1 proteins, such as JUNB and c-FOS, have been shown to...
A substantial proportion of esophageal carcinoma is associated with infection of high-risk HPV type 16 and HPV18, the oncogenic expression of which is controlled by host cell transcription factor Activator Protein-1 (AP-1). We, therefore, have investigated the role of DNA binding and expression ...
Effect of transcription factor AP-1 in chronic obstructivepulmonary disease; 转录因子AP-1在慢性阻塞性肺疾病中的作用 更多例句>> 3) Ets transcription factor family 转录因子Ets家族4) Transcription factor AP-4 转录因子AP-45) Transcription factor AP-2 转录因子AP-2 例句>> 6...