Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia pneumoniae infection. Cell. Microbiol. 15, 779-794.Wang, A.; Al-Kuhlani, M.; Johnston, S.C.; Ojcius, D.M.; Chou, J.; Dean, D. Transcription factor complex AP-1 mediates inflammation initiated by Chlamydia ...
Fas is a cell surface receptor that induces apoptosis upon oligomerization (1). Fas belongs to a family of related death receptors, including the receptors for tumor necrosis factor– (TNF- ) and the cytotoxic ligand TRAIL (1, 2). Fas-induced apoptosis has a critical role in maintaining ...
Transcription factors are regulatory proteins that modify gene expression. Any cellular function requiring alterations in mRNA levels depends upon these factors. The CNS, AP-1 (activator protein-1; c-fos and fos-related antigens plus jun-related factors)
The transcription factor AP-1 is a heterodimeric molecule, composed of members of the Jun (c-Jun, JunB and JunD) and the Fos family (c-Fos, FosB, Fra-1 and Fra-2). AP-1 family members are immediate early genes which are induced by a variety of stress signals and control subsequent ...
Studies using genetically modified mice have revealed fundamental functions of the transcription factor Fos/AP-1 in bone biology, inflammation, and cancer. However, the biological role of the Fos-related protein Fra-2 is not well defined... Robert,Eferl,Peter,... - 《Proceedings of the Nationa...
Hope B. T. (1998) Cocaine and the AP-1 transcription factor complex. Ann. N. Y. Acad. Sci. 844, 1-6.Hope BT. Cocaine and the AP-1 transcription factor complex. Ann N Y Acad Sci 1998;844:1-6. PMID: 9668659.Hope BT (1998). Cocaine and the AP-1 transcription factor complex. ...
We further identified that different concentrations of metformin induced different transcript profiles; however, significant enrichment in the activator protein 1 (AP-1) transcription factor network was common between the different treatments. Comparative analyses revealed that metformin induced divergent ...
The dimeric transcription factor complex Activator Protein-1 (AP-1) is a group of proteins involved in a wide array of cell processes and a critical regulator of nuclear gene expression during T-cell activation. It is also one of the downstream targets of the MAPK signaling cascade. In this...
Transcription factor AP-1 is a dimer formed by DNA-binding proteins of the Jun, Fos, and ATF families (activating transcription factor). AP-1 mediates the cell response to growth factors, cytokines, neurotransmitters, and other intercellular signaling molecules. Regulation of AP-1 activity involves...
(Fig.1c). Motifs for AP-1 complex as Fra1/2 were also enriched in these cell types. FOXA1 and GATA3 have been shown to be pioneer factors in MCF7 and K562, as they are the primary factor to bind DNA and modify the chromatin18,23. However, we found that the GRE motif is the ...