The activator protein-1 (AP-1) transcription factor family has been implicated in a multitude of physiologic processes and tumorigenesis; however, its role in MM is largely unknown. Here we demonstrate specific and rapid induction of the AP-1 family member JunB in MM cells when co-cultured ...
growth factor receptorsThis issue attempts to give a 'state of the art' overview of the AP-1 transcription factor family, a fundamental class of transcriptional regulators. The AP-1 family consists of several bZIP (basic region leucine zipper) domain proteins, the Jun, the Fos, and the ATF ...
AP-1 family transcription factor is a dimeric protein complex composed of heterodimers between Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra-1, and Fra-2), and ATF family gene products. From:Differentiation,2011 Also in subject areas: ...
The activator protein-1 (AP-1) proteins are a collection of transcription factors characterized by the presence of a basic leucine zipper (bZip) domain (Fig.1a). This family of proteins was first described in the 1980s whenv-Fosandv-Junwere identified as the oncogenic factors associated with ...
(ALK+ ALCL) are B and T cell lymphomas respectively, which express the tumour necrosis factor receptor superfamily member, CD30. Another feature shared by cHL and ALK+ ALCL is the aberrant expression of multiple members of the activator protein-1 (AP-1) family of transcription factors which...
Particularly, the level of expression of members of the AP-1 transcription factor family, such as c-Jun and c-Fos, has been shown to increase shortly after the exposure of cells to either mitogens or UV light (23, 60, 61). However, in order to exert its transcriptional activation ...
We focus on the role of the transcription factor AP-1 to both induce the expression of genes that function as invasion effectors and repress other genes that function as invasion suppressors. This identifies AP-1 as a critical regulator of a complex program of gene expression that defines the ...
In addition, PD-1 inactivation enforces ATP citrate lyase (ACLY) activity, which generates extramitochondrial acetyl-CoA for histone acetylation to enable hyperactivity of activating protein 1 (AP-1) transcription factors. Conversely, pharmacological ACLY inhibition impedes aberrant AP-1 signaling in PD...
A substantial proportion of esophageal carcinoma is associated with infection of high-risk HPV type 16 and HPV18, the oncogenic expression of which is controlled by host cell transcription factor Activator Protein-1 (AP-1). We, therefore, have investigated the role of DNA binding and expression ...
转录因子AP-1 1. Effect of transcription factor AP-1 in chronic obstructivepulmonary disease; 转录因子AP-1在慢性阻塞性肺疾病中的作用 更多例句>> 3) Ets transcription factor family 转录因子Ets家族4) Transcription factor AP-4 转录因子AP-45...