This may represent a novel pathway through which M22 induces apoptosis. Conclusions M22 treatment of cell cultures showed significant cytotoxicity, increased the population of sub-G1 cells and attenuated the expression of Bcl-2, Bax, pro-Caspase 9 and pro-Caspase 3. The drug also suppressed the...
Bertin, J. et al. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-κB.J. Biol. Chem.275, 41082–41086 (2000) ArticleCASGoogle Scholar Matsumoto, R. et al. Phosphorylation of CARMA1 plays a critical role in T Cell receptor-me...
Caspase-9 is one of the essential caspases which is required for the initiation of apoptosis signalling on the apoptosome complex through mitochondrial pathway and severe pathophysiological events will arise in case of failure to activate caspase-9 [12]. The activation of caspase 9 and downstream ...
The mitochondrial pathway in yeast apoptosis Apoptosis, 12 (2007), pp. 1011-1023 Google Scholar [262] F. Madeo, D. Carmona-Gutierrez, J. Ring, S. Buttner, T. Eisenberg, G. Kroemer Caspase-dependent and caspase-independent cell death pathways in yeast Biochem. Biophys. Res. Commun., 382...
Moreover, KP-induced cell apoptosis was likely to be mediated through the intrinsic apoptosis pathway since caspase 9 and caspase 7, but not BID, were shown to be activated after KP exposure. Based on the observation that KP induced apoptosis in HeLa cell, we further investigated the effects ...
英文名称Caspase-3 中文名称活化半胱胺酸蛋白酶蛋白-3抗体 别名Caspase-3 subunit p17; cleaved Caspase 3; cleaved Caspase-3; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds...
Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia. PeerJ 12, e2026 (2016)(PMID:27190722) Boada-Romero E et al. The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. Nat Commun. 7, 11821 ...
在作者的研究中发现,PKR抑制可阻碍BRAFV600EPTEN–/–黑色素瘤细胞中由anti-PD-L1抗体/IFN-γ所致的caspase-1裂解(Fig.8A),且anti-PD-L1抗体/IFN-γ在BRAFV600EPTEN–/–黑色素瘤细胞中可诱导PKR与NLRP3的结合(Fig.8B),而沉默...
(Grand Island, NY, USA). The bicinchoninic acid protein assay system was obtained from Thermo Scientific (Rockford, IL, USA). Antibodies against caspase 3 (Cell Signaling Technology, Beverly, MA, USA), BCL-2 (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA), cleaved caspase 9, BAX, ...