Caspase 3 activation was critical for apoptosis in A549 cells because this led to nuclear DNA fragmentation. Here we showed that up-modulation of Caspases 9 and 3, Apaf1 and Bax with the down-regulation of Bcl-2. This may represent a novel pathway through which M22 induces apoptosis. ...
As a member of type II interferon, IFNγ became well known for its immune-modulating effects on innate and adaptive immunity5. IFNγ could induce apoptosis of tumor cells through the caspase pathway and Fas/FasL-induced cell death. It can regulate the presentation of antigens, promotion of ...
The mitochondrial pathway in yeast apoptosis Apoptosis, 12 (2007), pp. 1011-1023 Google Scholar [262] F. Madeo, D. Carmona-Gutierrez, J. Ring, S. Buttner, T. Eisenberg, G. Kroemer Caspase-dependent and caspase-independent cell death pathways in yeast Biochem. Biophys. Res. Commun., 382...
Mechanistic study revealed that compound 111f exhibited good profile as apoptosis inducer via caspase-3 dependent pathway and arrested cell cycle at G1 phase in PC-3 cells line. A series of novel 7-amino- [1,2,4]triazolo[4,3-f]pteridinone derivatives 112–113 (Fig. 26) was designe...
英文名称Caspase-3 中文名称活化半胱胺酸蛋白酶蛋白-3抗体 别名Caspase-3 subunit p17; cleaved Caspase 3; cleaved Caspase-3; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds...
在作者的研究中发现,PKR抑制可阻碍BRAFV600EPTEN–/–黑色素瘤细胞中由anti-PD-L1抗体/IFN-γ所致的caspase-1裂解(Fig.8A),且anti-PD-L1抗体/IFN-γ在BRAFV600EPTEN–/–黑色素瘤细胞中可诱导PKR与NLRP3的结合(Fig.8B),而沉默...
Regulation of Caspase Expression and Apoptosis by Adenomatous Polyposis Coli The adenomatous polyposis coli (APC) gene, a member of the WNT pathway, has been shown to assign intestinal epithelial cells to a program of proliferation ... T Chen,I Yang,R Irby,... - 《Cancer Research》 被引量...
Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia. PeerJ 12, e2026 (2016)(PMID:27190722) Boada-Romero E et al. The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. Nat Commun. 7, 11821 ...
(Supplementary Fig.10F–I) tumor allografts fromCds2vMO-treated animals compared to controls. Treatment with the vMOs does not change the overall mass of the mice (Supplementary Fig.11B), and liver tissue fromCds2vMO-treated mice showed no increase in Caspase 3-positive apoptotic cells or ...
PS protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis through a pathway involving oxidative stress, p53, mitochondria, cytochrome C and caspase protease10. PS has been shown to suppress breast cancer stem cells with reducing the stem cell surface antigen CD44 ...