KIT(CD117), and HLA―DR; most are CD38-positive, with aberrant CD7 expression frequently observed. High CD34 expression is more common with inv(3) than with t(3;3). A subset of cases may express megakaryocytic markers such as...
There is generally expression of at least two markers characteristic of monocytic differentiation, such as CD14, CD4, CD11b, CD11c, CD64 (bright), CD68, CD36(bright), and lysozyme. 【翻译】一般来说至少表达两种单核系分化的特征性标志,如...
The following antigens: CD45, HLA-DR, CD34, CD117, CD13, CD33, CD19, CD7, cytoplasmic markers (CD3, CD79a, MPO), CD11c, CD14, CD64, CD42a, CD41 and CD61 were used. Results: Almost all AML blasts were expressing CD45 with no significant differences between the subtypes. CD34 have...
c-e, Quantification of proportion of cells expressing the indicated cell surface markers by flow cytometry analysis of primary AML samples cultured in serum-free medium supplemented with PBS control or GM-CSF (1 ng/mL) for one week. Data presented as mean +/- SEM of two independent AML ...
Detection of specific immunophenotypic markers (eg, CD13, CD33, CD34, CD117) is essential in classifying the acute leukemias. Commonly observed cytogenetic abnormalities in AML include t(15;17), trisomy 8, t(8;21), inv(16) or t(16;16) and 11q23.3 rearrangements (see table Commo...
Fc gamma receptorrisk assessmentRisk assessment in acute myeloid leukemia (AML) mainly relies on (cyto-)genetic and morphologic features. Nonetheless, further markers are needed to allow for accurate risk stratification. Type I Fc gamma receptors (FcγRs) such as CD16, CD32, and CD64 play ...
Here we show that certain subgroups of AML can be identified with a good accuracy (80% of the patients we analyzed) by means of the expression of specific markers. 展开 关键词: acute myeloblastic leukemia diagnostic FAB classification cell markers mathematical modelling ...
A population of cells characterized by markers expressed on the cell surface as determined by flow cytometry. Chimerism The relative proportions of human to mouse cells that result when human cells are engrafted into the bone marrow of immunocompromised mice. Clonal haematopoiesis of indeterminant potent...
(P114, P118, and P120; Fig.3b). To clarify this, we assessed the proportion of HSPC-like cells using flow cytometry by examining the expression of canonical stem cell markers (CD34 and CD117). Flow cytometry supported the scRNA-seq prediction and showed a high proportion (77.40% and ...
Churchill HRO, Fuda FS, Xu J, et al. Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation [published online ahead of ...