The purpose of this study was to compare the levels of the metabolites in question, mIns and taurine, in different mouse models of Alzheimer's disease: APP, PS1, APP-PS1 and wild-type. We hypothesized that the neurochemical profiles of these transgenic mice at old age would be genotype ...
we performed a GO enrichment analysis of the proteins which were upregulated by exercise and found 393 biological processes that were significantly enriched (p < 0.05) amongst the proteins of young mice and 233 in those of aged mice (Fig.3dand Supplementary Data6and7). Of these, ...
The role of nerve growth factor (NGF) and its receptors in the physiology of skeletal muscles has not been extensively studied in animal models. We describe the production of transgenic lines of mice expressing a neutralizing antibody against NGF (αD11) and the morphological and histochemical ana...
using the marker Iba-1, in both “gray” and “white” matter areas (cortex and corpus callosum), in the sagittal brain sections of all groups of mice following FMT (Fig.2and Fig. S1). Iba-1+microglial cell densities were higher in both the cortex and corpus ...
A reliable conventional (nontransgenic) animal model of cognitive decline would be a useful tool for preclinical drug testing. Therefore, we performed a comparative analysis of two potential models, namely, the aftin-4-treated mouse model and the aged mouse model, to evaluate their research value...
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-beta peptide and inhibits cerebral amylo... PM Mathews,TM Pawlik,D Schmidt,... - 《Nature Genetics...
2000. Plaque-associated a-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor pro- tein. Brain Res 853: 381 -383.Yang F, Ueda K, Chen P, Ashe KH, Cole GM. Plaque- associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor ...
In humans and laboratory rodent models (rats and mice), the ovaries exhibit age-related dysfunction relatively early in life, with failure noted long before aging-associated changes in other organs are manifest. In humans, this loss of ovarian function drives the menopause and its associated increa...
Muscular dystrophy in adult and aged anti-NGF transgenic mice resembles an inclusion body myopathy. Capsoni S,Ruberti F,Di Daniel E,et al. Journal of Neuroscience Research . 2000Capsoni S, Ruberti F, Di Daniel E, Cattaneo A: Muscular dystrophy in adult and aged anti-NGF transgenic mice...
Proteasome dysfunction in aged human alpha-synuclein transgenic mice. Neu- robiol Dis 2006;23(1):120-126.Chen L, Thiruchelvam MJ, Madura K, Richfield EK (2006) Proteasome dys- function in aged human alpha-synuclein transgenic mice. Neurobiol Dis 23:120 -126....