Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model. 2017;18:1–14. 23. Dunant NM, Senften M, Ballmer-Hofer K. Polyomavirus middle-T antigen associates with the kinase domain of Src- related tyrosine kinases. J Virol. 1996;70:1323–30. 24. Campbell KS, Ogris...
et al., 2008; Cardin et al., 2009). This technique allows the usage of a strong pan-neuronal promoter for ChR expression, while the selectivity is achieved by Cre-recombinase expression in the knock-in or BAC transgenic animal. This technique is currently only available in the mouse model....
A transgenic adenocarcinoma mouse prostate (TRAMP) model was generated by using a short regulatory region derived from the rat probasin promoter in order to direct the expression of heterologous proteins (Gingrich, J. R., et al., Cancer Res., 56:4096-4102, 1996; Greenberg, N. M., et al....
(2010) Anti-tumor necrosis factor ␣ treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C. Hepatology 52, 1553-1563.Brenndorfer, ED, Weiland, M, Frelin, L, Derk, E, Ahlen, G, Jiao, J et al. (2010). Anti- tumor necrosis ...
These alterations may be explained by an inhibition of cytochrome c in the majority of the tumor cells in a way similar to the possible suppression of cyclin D1 by c-Myc shown previously (Liao et al, 2000a). Alternatively, it may also be explained by an induction of cytochrome c in ...
Although amyloid beta (Aβ) imaging is widely used for diagnosing and monitoring Alzheimer’s disease in clinical fields, paralleling comparison between 18F-flutemetamol and 18F-florbetaben was rarely attempted in AD mouse model. We performed a comparison of Aβ PET images between 18F-flutemetamol an...
Results for insert positions were analysed by mixed-model nested ANOVAS with treatment as a fixed effect and positions nested within treatments as random effects, for both temperatures separately. Where p indicates positions and p(c) indicates posi- tions nested within treatments, the model was: ...
Thus, mouse models of HD can only mimic juvenile HD pathological changes whereas HD transgenic rats allow study of the common adult type of the disease [32]. Also, no significant loss of dopaminergic neurons is observed in the human alpha-synuclein transgenic mouse model of PD, but severe ...
Transgenic mouse model Adeno-associated virus Lentivirus 1. Introduction Alzheimer's disease (AD) is the most common neurodegenerative disease associated with age-related cognitive dysfunction [1]. There is currently no cure for AD, and treatment regimens only partially mask the symptoms while the dis...
25 The “brain shuttle” monovalent for TfR when applied to an anti-Aβ antibody has demonstrated efficacy at a lower dose than the corresponding monospecific Gantenerumab at decreasing amyloid plaque load in a Tg mouse model, but an effect on the cerebral pool of Aβ has not been shown.15...