These results suggest that in Neuro2a cells, mBG1-activated long-chain fatty acids are directed toward mitochondrial degradation, mBG1 appears to play a minor role in very long-chain fatty acid activation in these cells, indicating that other acyl-CoA synthetases are necessary for very long-...
Acyl-CoA synthetases 3 (ACSL3) belongs to a family of enzymes responsible for converting free long-chain FAs into fatty acyl-CoA esters, which act as substrates both for lipid synthesis and FAO. Here, we demonstrate that transforming growth factor beta 1 (TGFβ1) induces the up-regulation ...
The presence of long-chain acyl : CoA synthetases in mammalian microsomes and mitochondria has been established previously [(1971) Biochim. Biophys. Acta 231, 32-47]. The presence of a plasma membrane-associated enzyme was investigated in human erythrocyte ghost plasma membranes, where an enzyme ...
However, despite our rather thorough understanding of peroxisomal metabolic pathways, surprisingly little is known about the specific peroxisomal acyl-CoA synthetases that participate in these pathways. Of the 26 acyl-CoA synthetases encoded by the human and mouse genomes, only a few have been ...
Acyl-CoA synthetases (ACS) are a family of enzymes that convert fatty acid to fatty acyl-CoA esters. Currently, five isoforms of the long-chain subfamily of ACS (ACSL; ACSL1, 3-6) have been identified and characterized in rodents and humans [1]. These isoforms differ in their substrate ...
In view of the variety of biological effects described for these compounds the potential capacity of synthesis of diadenosine polyphosphates by the mammalian acyl-CoA synthetases may be relevant. 展开 关键词: Catalysis Coenzyme A Ligases: Metabolism Dinucleoside Phosphates: Biosynthesis Pseudomonas: ...
The length of the carbon chain of the fatty acid species defines the substrate specificity for the different acyl-CoA synthetases (ACS). On this basis, five sub-families of ACS have been characterized. The purpose of this review is to report on the large family of mammalian long-chain acyl...
Peroxisomal acyl-CoA synthetases Biochim. Biophys. Acta (2012) P.A. Watkins Fatty acid activation Prog. Lipid Res. (1997) L.O. Li et al. Acyl-CoA synthesis, lipid metabolism and lipotoxicity Biochim. Biophys. Acta (2010) Y. Cao et al. Expression of fatty acid-CoA ligase 4 during deve...
The activation of fatty acids occurs through the action of enzymes called fatty acyl-CoA synthetases, also known as fatty acid thiokinases. Fatty acyl-CoA synthetases catalyze the ATP-dependent formation of fatty acyl-CoA molecules by linking a fatty acid with coenzyme A (CoA). The resulting fa...
M2000 Overexpression of FAT/CD36 and Acyl-CoA Synthetases FATp2, FATP4 and ACSL1 Increases Fatty Acid Uptake in Hepatoma Cells licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. Received:...