This reaction is catalyzed by acyl-CoA synthetases (ACS). Investigation of these enzymes has revealed new and unexpected roles in health and disease. ACSBG1 is an ACS found only in neurons and in steroidogenic cells of the adrenal gland, testis, and ovary, and preferentially activates the 16-...
In view of the variety of biological effects described for these compounds the potential capacity of synthesis of diadenosine polyphosphates by the mammalian acyl-CoA synthetases may be relevant. Introduction Dinucleoside polyphosphates (NpnN) are molecules of crescent interest in metabolic regulation and...
Peroxisomal acyl-CoA synthetases Biochim. Biophys. Acta (2012) P.A. Watkins Fatty acid activation Prog. Lipid Res. (1997) L.O. Li et al. Acyl-CoA synthesis, lipid metabolism and lipotoxicity Biochim. Biophys. Acta (2010) Y. Cao et al. Expression of fatty acid-CoA ligase 4 during deve...
Acyl-CoA synthetases play a pivotal role in fatty acid metabolism, providing activated substrates for fatty acid catabolic and anabolic pathways. Acyl-CoA synthetases comprise numerous proteins with diverse substrate specificities, tissue expression patterns, and subcellular localizations, suggesting that each...
The activation of fatty acids occurs through the action of enzymes called fatty acyl-CoA synthetases, also known as fatty acid thiokinases. Fatty acyl-CoA synthetases catalyze the ATP-dependent formation of fatty acyl-CoA molecules by linking a fatty acid with coenzyme A (CoA). The resulting fa...
Acyl-CoA synthetases (ACS) are a family of enzymes that convert fatty acid to fatty acyl-CoA esters. Currently, five isoforms of the long-chain subfamily of ACS (ACSL; ACSL1, 3-6) have been identified and characterized in rodents and humans [1]. These isoforms differ in their substrate ...
Fatty Acyl-CoA Synthetases 来自 Semantic Scholar 喜欢 0 阅读量: 78 作者: Watkins,P.A.摘要: Fatty acyl-CoA synthetase (ACS) catalyzes the adenosine triphosphate dependent formation of a thioester bond between a fatty acid and coenzyme A. This fundamental reaction allows the fatty acid to be ...
M2000 Overexpression of FAT\\/CD36 and Acyl-CoA Synthetases FATp2, FATP4 and ACSL1 Increases Fatty Acid Uptake in Hepatoma Cells licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. Received...
M. tb). Biochemical studies on Fatty Acyl-CoA Synthetases (FadD13), one of the gene products of mymA operon, have provided insights into the involvement of this protein in the activation of fatty acids. Due to non-availability of the crystal structure of FadD13, we have employed in silico...
Long-chain acyl-CoA synthetases (ACSL) catalyze the conversion of fatty acids into fatty acyl-CoAs that are required for fatty acid metabolism. In this study, we demonstrate that expression levels of ACSL3 and 4 were oppositely regulated by androgen–AR signaling in prostate cancer cells. AR ...