A family of enzymes called acyl-CoA synthetases (ACSs) stands at a pinnacle step allowing influence over cellular acyl-chain selection and subsequent metabolic flux. ACSs perform the initial reaction for cellular fatty acid metabolism by ligating a Coenzyme A to a fatty acid which both traps a ...
Long chain acyl-CoA synthetases (ACSLs) activate fatty acids for intracellular metabolism but are also involved in the regulation of uptake. The predominant pathways for fatty acids are their storage, membrane biosynthesis, and conversion to energy. How activated fatty acids are channeled toward one ...
However, despite our rather thorough understanding of peroxisomal metabolic pathways, surprisingly little is known about the specific peroxisomal acyl-CoA synthetases that participate in these pathways. Of the 26 acyl-CoA synthetases encoded by the human and mouse genomes, only a few have been ...
Two long-chain acyl-CoA synthetases from Arabidopsis thaliana involved in peroxisomal fatty acid beta-oxidation. Plant J 2002 ; 32:93 - 103; http://dx... Jun,Rao,Litao,... - 《Gm Crops & Food》 被引量: 10发表: 2014年 A new type of peroxisomal acyl-coenzyme A synthetase from Arabido...
Presents information on the role of long-chain acyl-CoA synthetases (ACS) in channeling fatty acids toward complex lipid synthesis and storage or toward oxidation. Molecular characterization of rat ACS; Evidence for independent functions of ACS isoforms; Relationship between Acyl CoA partitioning and in...
To be utilized, all acetate, regardless of the source, must be converted to acetyl coenzyme A (acetyl-CoA), which is carried out by enzymes known as acyl-CoA short-chain synthetases. Acyl-CoA short-chain synthetase-2 (ACSS2) is present in the cytosol and nuclei of many cell types, ...
www.nature.com/scientificreports OPEN Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases received: 13 January 2016 accepted: 18 April 2016 Published: 03 May 2016 Tomomi Narita, Tatsuro Naganuma,Yurie Sase & Akio Kihara Transport of dietary lipids ...
Homologs of ACS, known as succinyl-CoA synthetases (SCS), have been characterized from eukaryotes as well as bacteria [32, 33]. As with the P. furiosus enzymes, their nucleotide specificity is determined by their β subunits [34], although these differ from those in the ACSs of the Thermo...
T. 2000. Trypanosoma brucei: Four tandemly linked fatty acyl-CoA synthetases. Experimental Parasitology96, 16–22. We have cloned four acyl CoA synthetase (ACS) genes from Trypanosoma brucei strain 927. Each of these genes encodes a polypeptide about 78 kDa in size and all four contain the "...
FIREFLY LUCIFERASE AND GENE PRODUCT ARE FATTY ACYL-COA SYNTHETASESM OJIKA