急性髓系白血病(Acute myeloid leukemia, AML)是最常见的白血病类型之一,且难以治愈。AML的特征在于快速增长的异常细胞,积聚在骨髓和血液中,进而干扰正常血细胞。其症状包括感到疲倦,呼吸急促,容易瘀伤和出血以及感染风险增加。AML的进展较为迅速,如果不及时治疗,通常会有生命危险。 临床研究,指任何在人体(病人或健康志...
Olsson, I., Bergh, G., Ehinger, M., Gullberg, U., 1996: Cell differentiation in acute myeloid leuk- emia. Eur. J. Haematol., 57: 1-16Olsson I, Bergh G, Ehinger M and Gullberg U (1996) Cell differentiation in acute myeloid leukemia. Eur. J. Haematol. 57: 1 ± 16...
Acute myeloid leukemia (AML) is a cancer that starts in the cells of your bone marrow that make different types of blood cells. It usually starts in a precursor cell to one type of white blood cell. Many of the symptoms of AML are nonspecific, which means they can be caused by several...
Acute myeloid leukemia( AML ) is a clonal and heterogeneous disease characterized by a myriad of genetic defects. 急性髓性白血病 ( acutemyeloid leukemia, AML ) 是一类起源于造血干细胞的、以大量遗传缺陷为特征的异质性恶性血液病. 互联网 Methods: Induction regiment ofacute myeloid leukemia( AML ) co...
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem cells (
Cancer vaccines are promising treatments to prevent relapse after chemotherapy in acute myeloid leukemia (AML) patients, particularly for those who cannot tolerate intensive consolidation therapies. Here, we report the development of an AML cell membrane-coated nanoparticle (AMCNP) vaccine platform, in ...
myeloid cell leukemia 1; miR: miRNA; mtDNA: mitochondrial DNA; PDC: pyruvate dehydrogenase complex; PDK: pyruvate dehydrogenase kinase; ROS: reactive oxygen species; SR4,9: dichlorophenyl urea compounds; CAC: citric acid cycle; UCP2: uncoupling protein 2; 2-DG: 2-deoxy-d-glucose; 3-BP: 3...
Traditionally, most acute myeloid leukemia (AML) subtypes have been distinguished from myelodysplastic syndrome (MDS) by the presence of at least 20% blasts in the bone marrow or peripheral blood, and for that reason, patients with blast levels that are elevated but less than 20% would typically...
Boyd, A., Reid, J., Salci, K.et al.Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche.Nat Cell Biol19, 1336–1347 (2017). https://doi.org/10.1038/ncb3625 Download citation
AcuteMyeloidLeukemia BySiTing WhatisAML?Acutemyeloidleukemia(AML)•isamalignanthematologicaldisorder•thebonemarrowmakesabnormalmyeloblasts—precursoroferythrocyte,plateletandgranulocyte•clonalproliferationofmyeloidprecursorcellswithreducedcapacitytodifferentiateintomorematurecells.Normally,thebonemarrowmakesbloodstemcells...