A phase 1b/2 study of TP-0903 and decitabine targeting mutant TP53 and/or complex karyotype in patients with untreated acute myeloid leukemia ≥ age 60 years: Phase 1b interim results.doi:10.1200/JCO.2022.40.16_suppl.70274117027#Background:TP-0903 is a multi-kinase inhibitor designed to ...
Acute myeloid leukemia CI: Confidence interval CR: Complete remission ELN: European Leukemia Net HR: Hazard ratio IKZF1MUT : IKZF1-mutated IKZF1WT : IKZF1-wild type CEBPA bZIP − inf − MUT : In-frame bZIP CEBPA-mutated OS: Overall survival RFS: Relapse-free survival ...
Acute myeloid leukemia (AML) is a group of heterogeneous hematologic malignancies characterized by numerous cytogenetic and molecular alterations. Activating mutations in theFMS-like tyrosine kinase 3(FLT3) gene represents the most frequent molecular abnormality in AML1,2. The majority of the mutations ...
The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated;CEBPADM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPANT), promoting expression of the leukemia-associated p30 isoform, and amorphic C-terminal mutations...
B-cell lymphoma 6 (BCL6) is a transcription repressor and proto-oncogene that plays a crucial role in the innate and adaptive immune system and lymphoid neoplasms. However, its role in myeloid malignancies remains unclear. Here, we explored the role of BCL6 in acute myeloid leukemia (AML)....
We screened out several hypermethylated solute carrier (SLC) family genes in acute myeloid leukemia by reduced representation bisulfite sequencing. SLC22A3 encodes an organic cation transport protein, which is critical for drug transportation and cellula
Allogeneic Stem Cell Transplantation in Secondary Acute Myeloid Leukemia and Myelodysplastic Syndrome: OHSU ExperienceTissue preparationsAdvanced therapy medicinal productsProcurement of tissuesLaboratory testingProcessingServicesSelected Questions Relating to Services Concerning the Procurement of Tissues and the ...
Inhibiting a protein that is overexpressed in the bone marrow of acute myeloid leukemia patients may prove valuable in treating the disease. Recent research has demonstrated the important role played by epigenetics in cancers – for example, disruption to a common mRNA modification known as m6A can...
Acute Myeloid Leukemia (AML) develops due to the acquisition of mutations from multiple functional classes. Here, we demonstrate that activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function mutations in the transcription factor CEBPA to promote...
Cancer Discov. https://doi.org/10.1158/2159-8290.Cd-19-0710 (2020). Jones, C. L. et al. Nicotinamide metabolism mediates resistance to venetoclax in relapsed acute myeloid leukemia stem cells. Cell Stem Cell https://doi.org/10.1016/j.stem.2020.07.021 (2020). Pei, S. et al. AMPK/...