Acute myeloid leukemia (AML) is a frequently fatal bone marrow stem cell cancer characterized by unbridled proliferation of malignant marrow stem cells with associated infection, anemia, and bleeding. An improved understanding of pathophysiology, improvements in measurement technology and at least 10 ...
Jennifer N.Saultz,Jeffrey W.Tyner, inBlood Reviews, 2023 1Introduction Acute myeloid leukemiais a heterogeneous clonal disorder marked by rapid proliferation of myeloid-lineage cells arrested at varying stages of maturation [2]. The acquisition of pre-leukemic mutations in normalhematopoietic stem cells...
Review article Efficacy and tolerability of isocitrate dehydrogenase inhibitors in patients with acute myeloid leukemia: A systematic review of clinical trials Leukemia Research Journal2023, Leukemia Research Wajeeha Aiman, ... Faiz Anwer 1 Introduction Acute myeloid leukemia (AML) is a hematologic malign...
Traditionally, most acute myeloid leukemia (AML) subtypes have been distinguished from myelodysplastic syndrome (MDS) by the presence of at least 20% blasts in the bone marrow or peripheral blood, and for that reason, patients with blast levels that are elevated but less than 20% would typically...
microRNAs (miRNAs) are known as potent gene expression regulators, and several studies have revealed the prognostic value of miRNAs in acute myeloid leukemia (AML) patient survival. Recently, strong evidence has indicated that miRNAs can be transported by exosomes (EXOs) from cancer cells to recipie...
Chemotherapy-resistant cancer recurrence is a major cause of mortality. In acute myeloid leukemia (AML), chemorefractory relapses result from the complex interplay between altered genetic, epigenetic and transcriptional states in leukemic cells. Here, we
Guidelines on the initial diagnostic workup of acute leukemia (AL) have been issued by the College of American Pathologists and the American Society of Hematology (CAP/ASH). [118] Guidelines for the management of acute myeloid leukemia (AML) have been issued by the following organizations: Nat...
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an incidence of over 20 000 cases per year in the United States alone. Large chromosomal translocations as well as mutations in the genes involved in hematopoietic prolifer
Global Acute Myeloid Leukemia (AML) Therapeutic Market: Overview As per Transparency Market Research, the global acute myeloid leukemia market (AML) therapeutics market will grow at a sturdy compound annual growth rate over the forecast period of 2020 to 2030 owing to growing incidence of AML. ...
The erythroid/myeloid subtype of acute erythroid leukemia (acute erythroleukemia [AEL]) is a malignant myeloid proliferation characterized by impaired maturation of the myeloid series, with excess myeloblasts occurring in a background of expanded maturing erythropoiesis. ...