Acute myeloid leukaemia (AML) is a disease of the elderly (median age at presentation 64 years). The outcome in older patients with AML is much worse than that for similarly treated younger patients. Older patients have a high incidence of recognised poor prognostic features (poor performance ...
Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of myeloid cells results in a high level of immature malignant cells and fewer differentiated red blood cells, platelets and ...
Acute myeloid leukemia is a highly malignant hematopoietic tumor that affects about 13,000 adults yearly in the United States. The treatment of this diseas... TJ Ley,ER Mardis,D Li,... - 《Nature》 被引量: 4472发表: 2008年 MiR-424 and miR-155 deregulated expression in cytogenetically no...
Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia The PI3K/AKT and mTOR signaling pathways are activated in acute myeloid leukemia, including in the more immature leukemic populations. Constitutive PI3K ac... S Park,N Chapuis,J Tamburini,... - 《Haematologica》 被引量...
AML, acute myeloid leukemia; GMP, granulocyte–macrophage progenitor; GSEA, gene set enrichment analysis; LAT2, linker for activation of T cells 2; LMPP, lymphoid-primed multipotent progenitor; NTAL, non–T cell activation linker; TCGA, The Cancer Genome Atlas. Table 2. Gene expression of NT...
Explore more information on the latest breakthroughs in the Acute Myeloid Leukemia treatment landscape of the report and Acute Myeloid Leukemia Pipeline Outlook @https://www.delveinsight.com/sample-request/acute-myeloid-leukemia-aml-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign...
Acute myeloid leukemia (AML) is considered acute because it progresses quickly if no suitable intervention is found, and can be very fatal in a short period [2]. Available data point to the fact that AML is the most common acute leukemia among adults, and its incidence increases with age ...
Current knowledge of the function and CD8+ T-cell recognition of LAAs is reviewed and an outlook is given on how to improve T-cell responses to LAAs in acute myeloid leukemia cells. 展开 关键词: Acute myeloid leukemia (AML cancer vaccines Leukemia-associated antigens (LAAs peptide vaccination ...
Advantages of biopharmaceuticals are being noted over conventional drugs and this is set to drive demand in the global acute myeloid leukemia therapeutics market. A strong pipeline of biopharmaceuticals currently marks the landscape, promising it a positive outlook in the future. Development of strong ...
Despite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains unfavorable due to inevitable chemotherapy resistance and high relapse rate, which mainly caused by the persiste