E. (2003) 'Human acute myeloid leukemia stem cells', Arch Med Res 34(6): 507-14.Human acute myeloid leukemia stem cells. Hope KJ,Jin L,Dick JE, et al. Archives of Medical Research . 2003K. J. Hope, L. Jin, J. E. Dick. Human acute myeloid leukemia stem cells. Archives of ...
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem cells (LSCs) that are implicated in AML development, chemoresistance, and relapse. An emerging area of research in AML focuses on identifying and targetin...
The stem cells of acute myeloid leukemia (AML) are the malignancy initiating cells whose survival ultimately drives growth of these lethal diseases. Here we review leukemia stem cell (LSC) biology, particularly as it relates to the very heterogeneous nature of AML and to its high disease relapse...
Cite this: Acute Myeloid Leukemia Stem Cells: Seek and Destroy - Medscape - Dec 01, 2009. Abstract and Introduction Models of Leukemogenesis LSC Biology & Unique Therapeutic Targets Expert Commentary Five-year View References SidebarRecommendations Revumenib Approved for R/R Acute Leukemia With KMT...
Acute myeloid leukemia (AML) is a clonal disorder defined by the accumulation of abnormally differentiated myeloid cells that are not mature; any myeloid lineage can be affected and the extent of maturation of the leukemia blasts can also vary. Because mature blast cells of AML have very limited...
Zhou HS,Carter BZ,Andreeff M.Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia:Yin and Yang[J].Cancer Biol Med,2016,13(2):248-259.Zhou, H.S.; Carter, B.Z.; Andreeff, M. Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid ...
Cancer vaccines are promising treatments to prevent relapse after chemotherapy in acute myeloid leukemia (AML) patients, particularly for those who cannot tolerate intensive consolidation therapies. Here, we report the development of an AML cell membrane-coated nanoparticle (AMCNP) vaccine platform, in ...
Progress in the understanding of the biology and therapy of acute myeloid leukemia (AML) is occurring rapidly. Since 2017, nine agents have been approved for various indications in AML. These included several targeted therapies like venetoclax, FLT3 inhi
molecules turning stem cells bad: generation of clinically relevant models of human acute myeloid leukemia through gene delivery-or genome editing-based ap... leukemia stem cellsviral vectorsxenotransplantsAcute myeloid leukemia (AML), the most common acute leukemia in the adult, is believed to ...
myeloid cell leukemia 1; miR: miRNA; mtDNA: mitochondrial DNA; PDC: pyruvate dehydrogenase complex; PDK: pyruvate dehydrogenase kinase; ROS: reactive oxygen species; SR4,9: dichlorophenyl urea compounds; CAC: citric acid cycle; UCP2: uncoupling protein 2; 2-DG: 2-deoxy-d-glucose; 3-BP: 3...