Immunotherapy in the form of allogeneic stem cell transplantation (SCT) plays an instrumental role in the treatment of acute myeloid leukemia (AML), with non-transplant modalities of immunotherapy including checkpoint blockade now being actively explored. Here, we provide an overview of the graft ...
Leukemia, Myeloid, AcuteMaleThe 10th United Kingdom Medical Research Council (MRC) AML trial showed a reduced overall relapse rate compared to previous trials, attributed largely to increased treatment intensity. Autologous...doi:10.1007/978-3-642-71960-8_126Goldstone, A. H....
EP: 1.Overview of Acute Myeloid Leukemia EP: 2.Current Classifications of Acute Myeloid Leukemia EP: 3.Molecular Biomarker Testing in Acute Myeloid Leukemia EP: 4.Acute Myeloid Leukemia: Optimizing Risk Stratification EP: 5.Role of Intensive Chemotherapy in Young, Fit Patients With AML EP: 6...
Progress in the understanding of the biology and therapy of acute myeloid leukemia (AML) is occurring rapidly. Since 2017, nine agents have been approved for various indications in AML. These included several targeted therapies like venetoclax, FLT3 inhi
Bone Marrow Transplant 2007;39:285-291.Huisman C, de Weger R, de Vries L, Tilanus MG, Verdonck LF. Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia. Bone Marrow Transplant. 2007;39(5):285-291. DOI: 10.1038/sj.bmt....
Infant Acute Myeloid Leukemia (IAML), which manifests within the first two years of life, represents a distinct subtype of childhood acute leukemia charact
Preliminary results of the safety of immunotherapy with gemtuzumab ozogamicin following reduced intensity allogeneic stem cell transplant in children with ... Myeloablative allogeneic stem cell transplantation (SCT) has been successful in the treatment of childhood acute myeloid leukemia (AML), but may be...
Allogenic hematopoietic stem cell transplantation (allo-HSCT) is one of the best therapies for acute myeloid leukemia (AML) and a proven post-remission therapy for intermediate and high-risk AML. The best HSCT source seems to be a matched sibling donor (MSD), but in the absence of one, a...
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an incidence of over 20 000 cases per year in the United States alone. Large chromosomal translocations as well as mutations in the genes involved in hematopoietic prolifer
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