stem cell transplantationrelapseCMVNatural killer (NK) cells play a major role in tumor surveillance, defense against viruses, and graft-versus-tumor effects after stem cell transplant (SCT). In acute myeloid l
Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia. Bone Marrow Transplant. 2007; 39 (5):285–91.Huisman C, de Weger RA, de Vries L, Tilanus MG, Verdonck LF. Chimerism analysis within 6 months of allogeneic stem cell trans-...
Acute myeloid leukemia (AML), the most frequent leukemia in adults, is driven by recurrent somatically acquired genetic lesions in a restricted number of genes. Treatment with tyrosine kinase inhibitors has demonstrated that targeting of prevalent FMS-related receptor tyrosine kinase 3 (FLT3) gain-of...
Leukemia, Myeloid, AcuteMaleThe 10th United Kingdom Medical Research Council (MRC) AML trial showed a reduced overall relapse rate compared to previous trials, attributed largely to increased treatment intensity. Autologous...doi:10.1007/978-3-642-71960-8_126Goldstone, A. H....
Bone marrow transplantDaunorubicinEjection fractionInductionSystolic functionIntroduction There is paucity of data regarding the cardiotoxic effects of anthracycline treatment in the context of acute myeloid leukemia (AML) patients who undergo allogeneic hematopoietic stem cell transplantation (HSCT). Even a ...
Acute myeloid leukemia (AML) is also called acute myelogenous leukemia. It is a fast-growing cancer of the bone marrow and blood cells. Cells that should become white blood cells (WBCs) do not fully grow. These cells are called myeloblasts and monoblasts. They do not fight infection like...
AML has also been called acute myeloid leukemia and acute non-lymphocytic leukemia [12, 13]. Leukemogenesis: risk factors AML is the result of a series of mutational events that occur in hematopoietic stem cells (HSCs) that include genetic and epigenetic alterations effectively altering normal ...
Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and
Stem Cell Transplants:are in their infancy in the UK as a treatment option. The stem cells may come from a family member (an allogeneic transplant) or may be your own (an autologous transplant) which were collected and frozen until you need them. In the USA, newly diagnosed patients under...
allogeneic stem cell transplantation; acute myeloid leukemia; refractory disease; graft-versus-host disease; reduced-intensity conditioning Abstract For patients with refractory acute myeloid leukemia (AML), allogeneic stem cell transplantation (alloSCT) represents the only curative approach. We here analyzed...