This chapter elaborates the mechanism of the action of antibiotics. Antibacterial antibiotics can be broadly classified according to their specific site and the mode of action as inhibitors of respiration and oxidative phosphorylation, cell-wall mucopeptide synthesis, cell membrane function, nucleic acid...
The mechanism of action of the antibacterial tripeptide AMC-109 is unclear. Here, Melcrová et al. show that AMC-109 self-assembles into stable aggregates with a cationic surface, and then individual peptides insert into the bacterial membrane and disrupt membrane nanodomains, thus affecting memb...
Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as ivermectin could be worthy of attention. This review article aims to discuss the pro
Besides antibacterial activities, AMPs have been found to possess a variety of biological functions, such as immune regulation, angiogenesis, wound healing and antitumor activity [6,7,8,9]. The treatment of pathogenic bacteria has been long-time mainly relied on antibiotics. However, the emergence...
Inhibition of Ceramide Synthesis in Plants by Phytotoxins Inhibition of ceramide synthase has recently been identified (Abbas et al., 1993c, d; Abbas and Shier, 1997; Abbas et al., 1998c; Vesonder et al., 1992) as the mechanism of action of a small group of phytotoxins isolated from ...
Mechanism of action of aminoglycoside antibiotics. Binding studies of tobramycin and its 6'-N-acetyl derivative to the bacterial ribosome and its subunits. Eur J of Biochem / FEBS. 1979; 102 (1):73–81. doi: 10.1111/j.1432-1033.1979.tb06264.x. [ Cross Ref ]...
The objectives of this study were to determine the antifungal activity of different parts of the M. communis plant against known standard ATCC Candida strains using methanol and sodium phosphate buffer extraction methods and to investigate the mechanism of action of these extracts on the growth inhibi...
1. Sehgal, Suren N. "Rapamune®(RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression." Clinical biochemistry 31.5 (1998): 335-340.
Despite intense study of AMPs on model membranes, we do not know how well the mechanism of attack translates to real biological membranes. To that end, we have characterized the attack of AMPs on Escherichia coli cytoplasmic membranes and directly compared this action to model membranes. AMPs ...
Mechanism of action Corticosteroids like triamcinolone inhibit phospholipase A2 on cell membranes, preventing the breakdown of lysosomal membranes of leukocytes, which in turn prevent the formation of arachidonic acid, which decrease expression of cyclooxygenase and lipoxygenase, inhibiting synthesis of prostag...