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Lateral membrane organization as target of an antimicrobial peptidomimetic compound The mechanism of action of the antibacterial tripeptide AMC-109 is unclear. Here, Melcrová et al. show that AMC-109 self-assembles into stable aggregates with a cationic surface, and then individual peptides inser...
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad...
Extraenteric amebiasis warrants treatment with other antimicrobial drugs.21 Genital infections/STIs Erythromycin can be used as an alternative drug in treating acute pelvic inflammatory disease caused by N. gonorrheae in female patients who have demonstrated hypersensitivity or intolerance to penicillin.21...
Shinabarger,Dean - 《Expert Opinion on Investigational Drugs》 被引量: 261发表: 1999年 Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1 Here, we report the successful design of a novel bacteria-selective antimicrobial peptide...
Rifampin is an antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis. Brand Names Isonarif, Rifadin, Rifamate, Rifater, Rofact Generic Name Rifampin DrugBank Accession Number DB01045 Background Rifampin, also known...
The antimicrobial activity of Pinipesin was tested. The haemolytic activity of the peptide was evaluated and its possible mechanism of action was investigated. Identification was carried out by mass spectrometry analysis. Pinipesin displayed potent antimicrobial effects against different microorganisms and ...
Invited reviewThe malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs Author links open overlay panelNatalie Jane Spillman a b, Kiaran Kirk aShow more Add to Mendeley Share Cite...
Mechanism of Action Chloramphenicol exerts its antimicrobial effects by inhibiting protein synthesis in bacteria. It achieves this by competing with messenger RNA for the binding sites on the bacterial ribosome necessary for peptide bond formation. Specifically, chloramphenicol binds reversibly to the 50S ...
As antimicrobial susceptibility patterns are geographically distinct, local antibiograms should be consulted to ensure adequate coverage of relevant pathogens prior to use. Mechanism of action Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S subunit of the bacterial ribosom...