Mechanism of action of an old antibiotic revisited: Role of calcium ions in protonophoric activity of usnic acidUsnic acidBilayer lipid membraneMitochondrial uncouplerProtonophoreMembrane potentialCalcium chelatorUsnic acid (UA), an old antibiotic and one of the first described mitochondrial uncouplers, ...
(MCP) antibiotics with potent antibacterial activity against CRAB. The mechanism of action of this molecule class involves blocking the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane, through inhibition of the LptB2FGC complex. A clinical ...
Mechanism of action Antibiotics active against bacteria are bacteriostatic or bacteriocidal; that is, they either inhibit growth of susceptible organisms or destroy them. On the basis of their mechanism of action, antibiotics are classified as (1) those that affect bacterial cell-wall biosynthesis, ...
7.15.4 Role of Apoprotein It is interesting that the naturally occurring enediyne antibiotics discovered so far can be easily divided into two major classes according to their enediyne core: one with a 10-membered ring, such as the calicheamicins (2), the esperamicins (3), namenamicin (8...
S. Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. Antimicrob. Agents Chemother. 52, 1703–1712 (2008). Article CAS PubMed PubMed Central Google Scholar Crowe-McAuliffe, C. et al. Structural basis of ABCF-...
Antibacterial research programs designed to structurally advance existing antibiotic classes profit from rapid in vivo mechanism of action confirmation. What is more, a comprehensive reference compendium of antibiotic proteomic signatures allows rapid mechanism of action identification of those structurally novel...
Single amino acids of these carrier proteins important for tetracycline transport and substrate specificity have been identified, allowing the mechanism of tetracycline transport to begin to emerge. 展开 关键词: Key words Antibiotic resistance Tetracycline resistance Ribosomal protection Efflux pumps Multidrug...
Antimicrobial peptide mode of action AMPs are receiving more attention, and new biophysical approaches are continually being developed, although the precise details of their molecular mechanism of action are still not fully understood. In bacteria with negatively charged surface layers made up of lipids...
Thecephalosporinshave a mechanism of action identical to that of the penicillins. However, the basic chemical structure of the penicillins and cephalosporins differs in other respects, resulting in some difference in the spectrum of antibacterial activity. Modification of the basic molecule (7-aminocep...
Bacteria become resistant to antibiotics by adapting their structure or function in some way as a defense mechanism. The antibiotic may have worked effectively before the resistance occurred; however, the change helps the bacteria to fend off the killing activity of the antibiotic....