: Mechanisms of antibiotic action . Pharmacol. Rev. 15 : 481 – 530 . 1963 .Gale, E. F. 1963. Mechanisms of antibiotic ac- tion. Pharm. Rev. 15: 481-530.Gale, E.F. (1963).Mechanism of antibiotics action .Pharmacol.Rev.15:481....
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns ...
Understanding the mechanisms of resistance by which bacteria successfully defend themselves against antibiotic assaults should facilitate the development of means to potentiate the efficiency and increase the lifespan of antibiotics. Resistance can be described in two ways: A) Intrinsic resistance whereby ...
mechanism of action (redirected fromMechanisms of action) Medical mech´an`ism of ac´tion n.1.(Medicine, Biochemistry)The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, themechanism of actionof actinomycin in...
Quinolone-resistant clinical Escherichia coli isolates were examined for mutations in the marRAB operon of the multiple antibiotic resistance (mar) locus. ... K Maneewannakul,SB Levy - 《Antimicrob Agents Chemother》 被引量: 335发表: 1996年 Cloning, sequencing and analysis of the enterocin biosynth...
The treatment of bacterial infections is increasingly complicated by the ability of bacteria to develop resistance to antimicrobial agents. Antimicrobial agents are often categorized according to their principal mechanism of action. Mechanisms include interference with cell wall synthesis (eg, β-lactams and...
1997. Fungicidal action of aureobasidin A, a cyclic depsipeptide anti-fungal antibiotic, against Saccharomyces cerevisiae. Antimicrob Agents Chemother 41(3):672–676 PubMed CAS Google Scholar Fairn, G. D., Curwin, A. J., Stefan, C. J., and McMaster, C. R. 2007. The oxysterol binding ...
Combinatorial events of insertion sequences and ICE in Gram-negative bacteria The emergence of antibiotic and antimicrobial resistance in Gram-negative bacteria is incremental and linked to genetic elements that function in a so-call... MA Toleman,TR Walsh - 《Fems Microbiology Reviews》 被引量: ...
Tigecycline is a bacteriostatic, parenteral glycylcycline antibiotic with a stronger (5-fold) binding affinity and structural similarities to the tetracyclines [4,14,27]. The main mechanism of action of tigecycline is similar to other tetracyclines in that it acts an inhibitor of bacterial protein ...
136 In both baseline and antibiotic-treated states, males and females show sex-specific microbiota profiles. However, antibiotic treatment alters expression of 940 genes in male APP mice but only one gene in equivalent females. Genes with lowered expression from baseline to antibiotic-treated in ...