Our data suggest that Pinipesin might be part of a prophylactic immune response during the ecdysis process of centipedes. Therefore, it is a promising candidate for the development of non-conventional antibiotics that could help fight infectious diseases and represents an exciting discovery for this ...
and anticancer peptides, have been widely studied and are promising drug candidates to compensate conventional antibiotics and chemotherapeutics1A number of factors believed to be important for biological activities of MAPs have been identified, including the presence of both hydrophobic and basic residues,...
Some of the factors contributing to increased infections in immunocompromised patients include the use of intravenous catheters, invasive procedures, and total parenteral nutrition and the increasing use of broad-spectrum antibiotics, cytotoxic chemotherapies, and transplantation [7]. The virulence factors ...
14 Resistance to clindamycin may develop, and is generally the result of base modification within the 23S ribosomal RNA. Cross-resistance between clindamycin and lincomycin is complete, and may also occur between clindamycin and macrolide antibiotics (e.g. erythromycin) due to similarities in their ...
This molecule participates in quorum sensing in Candida, preventing the transition from yeast to mycelial forms and thereby the formation of biofilms, which are more resistant to antibiotics.6,7 In addition, farnesol is an inhibitor of drug efflux ABC transporters, namely Candida CaCdr1p and Ca...
The L870, 812 series of compounds was not developed further, but the dihydroquinoline JTK303/GS9137 (Figure 2) derived from quinolone antibiotics was used for further drug development and is now at the advanced clinical development stage, under the name of elvitegravir [80]. Development of ...
Antibiotics-Mediated Depletion of Gut Microbiota Blocks Oral Melatonin-Induced Improvements on Circadian Rhythm Disruption-Triggered Lipid Intake in Ileum and Lipid Accumulation in eWAT To investigate whether oral MT-induced improvements on circadian rhythm disruption-triggered lipid intake in ileum and lipid...
They also received the same conventional treatment for the duration of this study, including the managing of blood pressure, blood glucose, and application of antibiotics. Collection of the gel-CM To obtain the gel-CM, 1 mL of the SVF-gel from the patients with chronic wounds was equally ...
Divo AA, Sartorelli AC, Patton CL, Bia FJ: Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1988 Aug;32(8):1182-6. [Article] Enzymes Details1. Cytochrome P450 1A2 Kind Protein Organism Humans Pharmacological action Unknown Actions Inhibitor...
Vancomycin is a branched tricyclic glycosylated nonribosomal peptide often reserved as the "drug of last resort", used only after treatment with other antibiotics has failed. Vancomycin has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical in...