Sperm-mediated gene transfer (SMGT) is a procedure through which new genetic traits are introduced in animals by exploiting the ability of spermatozoa to take up exogenous DNA molecules and deliver them to oocytes at fertilization. The interaction of exogenous DNA with sperm cells is a regulated ...
we validated with fluorescence microscopy that teixobactins are able to efficiently capture Lipid II in clusters in anionic membranes (Supplementary Fig.13). While cluster formation was previously only observed for lantibiotics18, it is hence a more common mode of action of antibiotics that target ...
Keyes K, Lee M, Maurer J (2003). Antibiotics: Mode of Action, Mechanisms of Resistance and Transfer. Microbial Food Safety in Animal Agriculture Current Topics. ME Torrence and RE Isaacson, eds. Iowa State Press, Ames, Iowa, USA.Keyes K, Lee MD, Maurer JJ.(2003). Antibiotics: Mode of...
n.1.(Medicine, Biochemistry)The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, themechanism of actionof actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identifi...
For the first time, researchers have been able to observe the mode of action of a promising class of alternative antibiotics directly in bacterial cellular membranes. Until now, such studies could only be done in less relevant media, such as organic solvents or micelles. The approach they develo...
The mode of action of some antibiotics in their inhibitory effect on tobacco mosaic virus multiplication1)doi:10.1111/j.1439-0434.1960.tb01915.xT. HiraiT. ShimomuraJohn Wiley & Sons, LtdJournal of Phytopathology
Most candidate anti-bacterials are identified on the basis of their whole cell anti-bacterial activity. A critical bottleneck in the early discovery of novel anti-bacterials is tracking the structure activity relationship (SAR) of the novel compounds syn
techniques with the more classical approach of focussing on understudied, extremophilic, “unculturable” (so far not cultured) bacteria or rare bacterial genera, provides a rich ground for the discovery of new mode-of-action antibiotics. We therefore decided to investigate the metabolome of the ...
Pantoea agglomerans, a common bacterial species of the phyllosphere from apple and pear, has often been described to act antagonistic against Erwinia amylovora (1). Several strains of P. agglomerans have been shown to act by the production of antibiotics (2). Wright and Beer (1997) described...
The genes have been divided into three base groups related to their amino acid sequences rather than G+C% content as is done with the efflux genes.Bacterial Resistance to Antibiotics – From Molecules to Mandoi:10.1002/9781119593522.ch5Marilyn C. Roberts...