In this process, unlike the pore models, no peptide insertion into the membrane, peptide-peptide interaction and any particular peptide structures are formed [42]. Cecropin [60], indolicidin [61], aurein 1.2 [62], and LL-37 [51] are some of the AMPs to follow this mode of action. ...
The survival and growth of microorganisms depend on the cell integrity and, consequently, proper function. Therefore, an antimicrobial chemical agent or material may be classified according to the mode of action against cells' function or integrity. If their effect happens just due to the inhibition...
The selection of a technique for synthesizing NVs depends on the nature of the material, type of NVs and its application in different fields. Currently, nanotechnology is applied in almost all fields including medical, energy, electronics, chemistry, physics, materials science and defence. Among ...
action plans may be scarce in poor parts of the world, and more fundamental issues may as well be of greater relevance. To combat AMR, we must enable low- and middle-income countries (LMICs) to implement sustainable sanitation, secure nutrition, and access to proper health care thereby ...
(I) sites47. Generally, this bridging mode of the quinoxaline ligands is usual in its complexes54,55. Unexpectedly, the 2-chloroquinoxaline in the studied complexes acts as a terminal monodentate ligand rather than a connector where the coordination with Ag(I) occurs only through one nitrogen ...
Bacteria and fungi contribute to antibiotic resistance, posing a growing threat to human health, while cervical cancer remains a significant health concern, impacting women's well-being and mortality rates worldwide. In the present work, the efficiency of formulated tin oxide-sodium alginate-polyethyle...
almost one-fourth of the global population, are estimated to be currently infected by Mtb but are in the dormant stage (also referred to as latent tuberculosis infection) [2]. Considering the financial burden and common occurrence of drug resistance during the usual 6-month regimen (in non-com...
were restored in 16HBE cells exposed to CSE and SARS-CoV-2 and treated withLr.Lrinduces antiviral signaling associated to IFN-γ secreting viral sensors and attenuates cytokine storm associated to NF-κB in bronchial epithelial cells, supporting its emerging role in prevention of COPD exacerbation....
We showed that host epithelia displayed up-regulated autophagy activity after long-term repeated bacterial infection to eliminate intracellular microbes, which supported a critical window for bacteria-dependent tumor hyperproliferation and its decoupling from late-stage cancer growth. A driver–passenger ...
In this context, we analyzed the possible synergistic activity of a novel antimicrobial peptide, P5, with meropenem (member of the carbapenem class of β-lactam antibiotics) and its potential as antibiofilm agent. The cationic AMP P5 was previously designed by some of us and evaluated in vitro ...