This article has traced the development of a strategy for mode of action studies of chemotherapeutic drugs from its blindfolded empirical beginnings to the current state in which it is possible to assign a category of mode of action to a given substance within a limited period of investigative ...
This introductory chapter is an overview of targets for antimicrobial action and mechanisms of bacterial resistance combined with information on the nature of antibacterial drugs, their classification, and their usage in animals. On the basis of the target microorganism, drugs are classified as ...
网络作用型态 网络释义 1. 作用型态 ─奈米物质对生态物种的作用型态(modes of action)。 www.epa.gov.tw|基于 1 个网页 例句
Membrane disrupting peptides: Mechanistic elucidation of antimicrobial activity Membrane-disrupting peptides have long been considered as promising anti-infective and anticancer agents. Over the last decade significant progress has been made in the elucidation of their modes of action using high-resolution...
Cross-resistance, a phenomenon that a pathogen resists to one antimicrobial compound also resists to one or several other compounds, is one of major threats to human health and sustainable food production. It usually occurs among antimicrobial compounds sharing the mode of action. In this study, ...
The emerging resistance of crop pathogens to fungicides poses a challenge to food security and compels discovery of new antifungal compounds. Here, we show that mono-alkyl lipophilic cations (MALCs) inhibit oxidative phosphorylation by affecting NADH oxidation in the plant pathogens Zymoseptoria tritici,...
T., and De Bruijn, E. A., Cytotoxic activity of 7-N-(2-((2-(γ-L-glutamylamino)-ethyl)dithio)ethyl)-mitomycin C and metabolites in cell lines with different resistance patterns. Anti-Cancer Drugs, 5, 343–354 (1994). Article PubMed CAS Google Scholar ...
This approach accounts for many of the most important drugs in current antimicrobial therapy. There are, however, several valuable drugs whose various modes of action fall outside those most commonly encountered. In this chapter we describe some important examples of compounds with unusual actions ...
While novel antimicrobial drugs, such as antimicrobial peptides, are urgently needed, identification of new modes of action is money and time consuming, and in addition current approaches are not available in a high throughput manner. Here we explore how small angle X-ray scattering (SAXS) as ...
In recent years there has been great interest in novel ways of distributing therapeutic agents, primarily antimicrobial drugs, by means of local applications to target tissues within the musculoskeletal system of horses. The primary goal has been to deliver high and sustained therapeutic concentrations ...