When a new antimicrobial compound is introduced from a research outcome, the main objective is to concentrate on its mode of action, which should be more specific to the target organisms as well as less hazardous to the environment. Wheat is the most demanding cereal crop globally. But due ...
It was estimated that the flora of Saudi Arabia has a great medicinal species diversity, which is expected to be more than 1200 (over 50%) out of its 2250 species[1]. Hence, the present study was designed to investigate the cytotoxicity and the antimicrobial activities of twenty six Saudi ...
To study the molecular basis of its antimalarial action, we tested X5 and selected hydroxyxanthone analogs as inhibitors of in vitro heme polymerization in a low ionic strength phosphate solution at mildly acidic pH. We found that addition of 1 Eq. of X5 resulted in complete inhibition of ...
)whilstmaintaininganantimicrobialactivityinthe0.5–4μMrange.Experimentswithmonomeric,dimericandfluorescentlylabelledversionsoftheadepantins,usingdifferentbacterialstrains,hostcellsandmodelmembranesystemsprovidedinsightintotheirmechanismofaction.©2012ElsevierB.V.Allrightsreserved.1.IntroductionNewanti-infectiveagents...
Hobson, C., Chan, A. N. & Wright, G. D. The antibiotic resistome: A guide for the discovery of natural products as antimicrobial agents.Chem. Rev.121, 3464–3494 (2021). ArticleCASPubMedGoogle Scholar Doroghazi, J. R.et al.A roadmap for natural product discovery based on large-scal...
The rapid increase of antibiotic resistance has created an urgent need to develop novel antimicrobial agents. Here we describe the crystal structure of the promising bacterial target phospho-N-acetylmuramoyl–pentapeptide translocase (MraY) in complex with the nucleoside antibiotic tunicamycin. The structur...
The mechanism of action of antimicrobial agents can be categorised based on the function that is affected by the agents, these generally included the following: inhibition of the cell wall synthesis, inhibition of ribosome function, ... A Dowling,J O'Dwyer,C Adley 被引量: 4发表: 2017年 The...
P1665 Mode of action and resistance of the new fluoroquinolone BOL-303224-A - International Journal of Antimicrobial Agentsdoi:10.1016/S0924-8579(07)71504-2Cambau, E.Lepage, J.F.Matrat, S.Pan, X.S.Roth dit Bettoni, R.Corbel, C....
Antimicrobial Agents and Chemotherapy 48: 2838–2844 doi:–10.1128/AAC.48.8.2838–2844.2004. [13] Parsons AB, Lopez A, Givoni IE, Williams DE, Gray CA, et al. (2006) Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast. Cell 126: 611–625 doi:...
Comparably little is known about the mode of action of 5-nitroimidazoles in G. lamblia. In general, these drugs are considered to damage DNA (Edwards, 1993) but it has as yet not been conclusively demonstrated that this damage is caused by direct attack of 5-nitroimiazoles on DNA rather ...