Journal of Dairy ScienceRadisson, J., C. Smith, et al. (1956). "The mode of action of antibiotics in the nutrition of the dairy calf. I. Effect of terramycin administered orally on the performance and intestinal flora of young dairy calves." J Dairy Sci 39: 1260-1267....
Antibiotic resistance is recognized by the CDC as a top global public health threat and requires action by the public and healthcare providers.
welldocumented,itsmodeofactionhashithertoremainedonlyvaguelydefined.Inthisworkweinvestigated theantimicrobialmodeofactionofchitosanusingacombinationofapproaches,includinginvitroassays, killingkinetics,cellularleakagemeasurements,membranepotentialestimations,andelectronmicroscopy,in ...
Mode of action of the cyclic depsipeptide antibiotic LL-AO341 beta 1 and partial characterization of a Staphylococcus aureus mutant resistant to the antibi... Chopra, Mode of action of the cyclic depsipeptide antibiotic LL-AO341 beta 1 and partial characterization of a Staphylococcus aureus mutant ...
The mode of action of the majority of these pepides has been demonstrated to be the permeabilization of the inner membrane. Such a mechanism has been demonstrated for α-helical, β-structured, and proline-/arginine-rich peptides either directly by in vivo assay or indirectly by their effect...
et al. Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science 286, 2361–2364 (1999). Article CAS PubMed Google Scholar Hasper, H. E. et al. An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II. Science 313, 1636...
Here we resolve the mode of action of darobactin at the atomic level using a combination of cryo-electron microscopy, X-ray crystallography, native mass spectrometry, in vivo experiments and molecular dynamics simulations. Two cyclizations pre-organize the darobactin peptide in a rigid β-strand...
Improper antimicrobial practices expedite the evolution of antibiotic-resistant and super-drug-resistant bacteria, and result in varied and elevated antibiotic resistance throughout the world. The dominant problem with antibiotic therapy is the antibioti
www.nature.com/scientificreports OPEN The mode of action of plant associated Burkholderia against grey mould disease in grapevine revealed through traits and genomic analyses Qassim Esmaeel*, Cédric Jacquard, Lisa Sanchez, Christophe Clément & Essaid Ait Barka* Plant-...
bacteria, including clinically relevant MRSA. Mode-of-action experiments indicated that tatiomicin may act as a Michael acceptor in vitro, an electrophile that can undergo conjugate addition reactions with biomolecules, and exhibits its antibiotic activity via a pathway involving membrane depolarisation ...