The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells. J Leukoc Biol 2002; 72: 1027–36.Bshesh K, Zhao B, Spight D, Biaggioni I, Feokistov I, Denenberg A, Wong HR, Shanley TP. The A2A receptor mediates an endogenous regulatory pathway of ...
CGS 21680 Hydrochloride 是一种 adenosine A2A receptor 激动剂,Ki值为 27 nM。 产品性质 英文别名 (English Synonym) CGS 21680 Hydrochloride 中文名称 (Chinese Name) / 靶点 (Target) A2 通路 (Pathway) GPCR/G Protein CAS号 (CAS NO.) 124431-80-7 分子式 (Formula) C23H30ClN7O6 分子量...
Key words: scar hyperplasia; adenosine A2A receptor; antagonist; PI3K pathway; TGF-β1; collagen 瘢痕增生是创面修复的方式之一,以成纤维细胞异常增殖、细胞外基质尤其是胶原过度沉积为特征,形成瘢痕时不仅影响外观,还可引起疼痛、瘙痒等症状,严重时还会影响关节功能[1-3]。目前,瘢痕增生的机制尚未完全阐明,临床...
然而,A2A受体在角膜伤口愈合中的作用尚未见报道。 2024年6月15日,陈江帆/郭卫团队在经典药理学期刊British Journal of Pharmacology(我校高质量共识期刊)上发表题为“An agonist of the adenosine A2A receptor, CGS21680, promotes corneal epithelial wound healing via the YAP signaling pathway”的研究论文。该研究...
to different G proteins in different areas and a variety of downstream signaling pathways, including cAMP-dependent, phospholipase C–dependent, and stimulation or inhibition of extracellular signal regulated kinase 1/2 via the cAMP-ras-MEK1 pathway have been implicated in signaling at this receptor...
通路(Pathway) GPCR/G Protein--Adenosine Receptor CAS号(CAS NO.) 155270-99-8 分子式(Formula) C20H24N4O4 分子量(Molecular Weight) 384.43 外观(Appearance) 粉末 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 结构式(Structure) 运输和保存方法 ...
Ke-Jie Mou1, Kai-Feng Shen, Yan-Ling Li, Zhi-Feng Wu and Wei Duan,Adenosine A2A Receptor in Bone Marrow-Derived Cells Mediated Macrophages M2 Polarization via PPARγ-P65 Pathway in Chronic Hypoperfusion Situation,Front. Aging Neurosci., 03 January 2022 |校对编者: 原代美少女 (Brainnews艺术创作...
Ke-Jie Mou1, Kai-Feng Shen, Yan-Ling Li, Zhi-Feng Wu and Wei Duan,Adenosine A2A Receptor in Bone Marrow-Derived Cells Mediated Macrophages M2 Polarization via PPARγ-P65 Pathway in Chronic Hypoperfusion Situation,Front. Aging Neurosci., 03 January 2022 |转译所作: 原代真人版 (Brainnews创作团...
Ke-Jie Mou1, Kai-Feng Shen, Yan-Ling Li, Zhi-Feng Wu and Wei Duan,Adenosine A2A Receptor in Bone Marrow-Derived Cells Mediated Macrophages M2 Polarization via PPARγ-P65 Pathway in Chronic Hypoperfusion Situation,Front. Aging Neurosci., 03 January 2022 |编译作者: 原代美少女 (Brainnews创作设计...
Autophagy, a homeostatic pathway upregulated during cellular stress, is decreased in osteoarthritic chondrocytes and this reduction in autophagy is thought to contribute to the development and progression of osteoarthritis (OA). The adenosine A2A receptor (A2AR) is a potent anti-inflammatory receptor an...