Purinergic receptors have been proposed as possible targets for treatment in different neurodegenerative disorders due to the fact that the A1 and A2 receptor functions were associated with neuromodulator effects within the brain. Adenosine A1 receptors (A1Rs) are widely distributed in the brain of ...
Agonist-induced desensitization of A1 and A2 adenosine receptors was studied in brain slices obtained from either rat striatum or cortex, exposed to the adenosine analogue N6-cyclopentyl adenosine (CPA) for selected time periods (15-60 min), and repeatedly washed at the end of agonist exposure. ...
Ghai G, Zimmerman MB and Hopkins MF. (1987) Evidence for A1 and A2 adenosine receptors in guinea pig trachea. Life Sci 41(10):1215-1224.Ghai, G., Zimmerman, M.B., and Hopkins, M.F. Evidence for A1 and A2 adenosine receptors in guinea pig tra- chea. Life Sci., 41:1215-1224, ...
The difference between A1 and A2 beta-casein is as tiny as can be—a single amino acid in the long chain that makes this protein. A1 casein contains the histidine amino acid as the 67th link in its chain, while A2 casein contains proline there. Tiny Difference With Huge Consequences Howe...
AMP 579 Reduces Contracture and Limits Infarction in Rabbit Heart by Activating Adenosine A2 Receptors SUMMARY: To determine the mechanism by which AMP 579, an adenosine A1/A2 agonist, administered at reperfusion protects ischemic myocardium, buffer-perfused... Z Xu,JM Downey,MV Cohen - 《Journal...
whereas in basal breast cancer, the role of FOXA1 is determined by ESR1. Therefore, when targeting FOXA1 for treating breast cancer, we should first distinguish the type of breast cancer, detect the expression of related hormone receptors, and finally decide the treatment plan according to these...
Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A1 receptors (A1Rs) and the less abundant, but widespread, facilitatory A2ARs. It is commonly assumed that A1Rs play a key role in neuroprotection since they decrease glutamate release and hyperpolarize neurons....
There are two families of T cells, αβ T cells and γδ T cells, defined by their T cell receptors (TCRs). Knowledge about how αβ T cells recognize their antigens has expanded greatly over the past 40 years5. The common feature of antigen recognition by αβ T cells is that all...
Roles for adeno- sine A1- and A2-receptors in the control of thyrotrophin and prolactin release from the anterior pituitary gland. Regul Pept 79: 41-46, 1999.Kumari M, Buckingham JC, Poyser RH, Cover PO. Roles for adenosine A1- and A2-receptors in the control of thyrotrophin and ...
of endogenous AMPA receptors (AMPARs), the principal mediators of fast excitatory synaptic transmission, are specifically exchanged. These mice display profound deficits in synaptic plasticity without any effects on basal synaptic transmission. Our study reveals that the CTDs of GluA1 and GluA2, the...