Subtype selectivity, efficacy, and signaling bias are major factors to be considered in designing drugs with low side effects, and it is increasingly recognized that understanding the dynamical aspects of receptor signaling is key to grasping these processes. While it is tempting to string together ...
(α_2-adrenoceptors) belong to the family of seven transmembranne-spanning G-protein-linked receptors, α_2-Adrenoceptors can be grouped into three highly homologous subtypes (α_2a α_2B and α_2C) and, be-causeof the difference in pharmacology a fourth subtype(α_2D) can be formally ...
, 1992), perhaps this response may occur through activation of another receptor, such as the A2b subtype, since the concentration required is above the range of A2a receptors. COS-7 cells transfected with the wild type Tag3-A2a receptor showed a pronounced stimulation of cyclic AMP production ...
Single-molecule fluorescence spectroscopy methods have been previously applied to study GPCR conformational dynamics7. For example, environmentally sensitive fluorescent dyes have been used as single-molecule reporters of conformational changes in the β2adrenergic receptor (β2AR)26,27,28,29, visual rhod...
Adenosine-induced relaxation appeared to involve the A2a receptor, but not the A2b subtype. Conclusions It was concluded that adenosine relaxation in NE-precontracted rat aortic rings was triphasic and endothelium-dependent above 10 μM, and relaxation involved endothelial nitric oxide (not prostanoids...
蛋白别名为:ADRA2A; ADRA2R; ADRAR; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR;基因ID为:150;蛋白质ID:P08913 【应用类型】:WB,IF,ELISA补充:*优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB...
ADRA2A encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.蛋白别名为:ADRA2A; ADRA2R; ADRAR; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR;基因ID为:150;蛋白质ID:...
In HEK293 cells, the γ7 subtype is responsible for driving the assembly of a particular Gs heterotrimer required for β adrenergic and D1R signaling but not for PGE2 and D5R signaling (61, 62); and in the physiological relevant context of the brain, it is responsible for driving the ...