Background The A 2A adenosine receptor has become a drug target in the treatment of Parkinson's disease, psychotic behavior and dementia. In addition, targeted deletion of this receptor in mice leads to hypertension, increased platelet aggregation, male aggressiveness and decreased susceptibility to ...
靶点(Target) Adenosine A2A receptor 通路(Pathway) GPCR/G Protein--Adenosine Receptor CAS号(CAS NO.) 155270-99-8 分子式(Formula) C20H24N4O4 分子量(Molecular Weight) 384.43 外观(Appearance) 粉末 纯度(Purity) ≥98% 溶解性(Solubility)
This chapter discusses two case studies regarding drug-target residence time (RT) at adenosine receptors. Compared to current kinetic assays, the introduce... G Dong,AP Ijzerman,LH Heitman - John Wiley & Sons, Ltd 被引量: 2发表: 2015年 Comparative Study of Receptor-, Receptor State-, and...
19,35yet there still lacks a more comprehensive description of signaling pathways downstream of CGRP receptor in OSCC. CGRP receptor functions through a complex involving a dimerized RAMP1/CLR cross membrane complex and an intracellular receptor component protein (RCP), which fine-tunes the...
The adenosine A2A receptor (A2AR) represents a drug target for a wide spectrum of diseases. Approaches for targeting this membrane-bound protein have been greatly advanced by new stabilization techniques. The resulting X-ray crystal structures and subsequent analyses provide deep insight to the A2AR...
Conformational changes in the G protein Gs induced by the beta2 adrenergic receptor Nature, 477 (2011), pp. 611-615 CrossrefGoogle Scholar de Lera Ruiz et al., 2014 M. de Lera Ruiz, Y.H. Lim, J. Zheng Adenosine A2A receptor as a drug discovery target J. Med. Chem., 57 (2014),...
S Humez1,2, CE Müller5, LV Lopes4, L Buée1,2,10 and D Blum1,2,10 Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse model...
Adenosine A2Areceptors modify motor function in MPTP-treated common marmosets. Kanda et al. Neuroreport, 1998;9:2857 Actions of adenosine A2Areceptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by rese. or MPTP.
We aim to investigate the role of A2A receptor in peritonitis-related sepsis by injection of a fecal solution (FS) as a model of polymicrobial infection. C57/black J6 wild-type (WT) and A2A-deficient mice (A2AKO) were exposed to sepsis induced by intraperitoneal injection of a FS (FS-in...
Recently, Istradefylline (IST) was approved by the FDA for treating Parkinson's disease, representing a safe drug that acts through the inhibition of the A2A receptor, and it has also been suggested as an antineoplastic drug. Therefore, this work aims to explore the effects of A...