9. D'Agostino, G., et al. Nucleus of the Solitary Tract Serotonin 5-HT(2C) Receptors Modulate Food Intake. Cell metabolism28, 619-630.e615 (2018).想了解更多精彩内容，快来关注BioArt生物艺术
缺乏功能性5-ht2c受体的突变小鼠也容易从癫痫发作中自发性死亡(eatingdisorderandepilepsyinmicelacking5-ht2cserotoninreceptors;tecott,l.h.etal.,nature.1995apr6;374(6522):542-6)。此外,在选择性血清素再摄取抑制剂西酞普兰作为具有控制不佳的癫痫的非抑郁患者的添加治疗的初步试验中,中位癫痫发作频率下降了55.6...
Background:Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways...
While there is evidence for the involvement of different serotonin (5hydroxytryptamine; 5-HT) receptors in the regulation of food intake and body weight maintenance, the data supporting the role of the 5-HTreceptor are especially strong. This information has elevated 5-HTreceptor activation into ...
[1]. D L Nelson, et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):1-6. [2]. S L Shepheard, et al. Investigation of the effects of IVth ventricular...
Although it has been demonstrated that 5-HT2C receptors in the choroid plexus couple to PLC activity, additional functional correlates remain to be established. Hitherto, at least fourteen functional isoforms (and potentially many more) of the 5-HT2C receptor have been identified; produced by ...
[2]Perez Diaz M, Wilson ME, Howell LL. Effects of long-term high-fat food or methamphetamine intake and serotonin 2C receptors on reversal learning in female rhesus macaques. Neuropsychopharmacology. 2018.https://doi.org/10.1038/s41386-018-0200-z....
Serotonin 2C receptors (5-HT2CR) are known for their important role in anxiety, and mice having only the fully edited VGV isoform of 5-HT2CR, which thereby overexpressed brain 5-HT2CR, are of special interest to study PTSD predisposition. Innate and conditioned fear-related behaviors wer...
(5hydroxytryptamine2Creceptors,5HT2C)基因被破 坏的小鼠表现出的癫,伴有偶发和自发的急性发作 而导致死亡,较正常的小鼠有较低的癫域值 [3] 。这 说明5HT2C受体可能参与了癫的发病,其表达量的 多少可能会影响癫的发病,提示若能提高5HT2C 受体的含量,可能会抑制癫的发病。
Additionally, we identified a novel editing site in the middle edited codon that extends the repertoire of 5-HT2C receptors by six additional protein isoforms. We observed that editing reduces both the binding affinity and functional potency of agonists for recombinant human 5-HT2C receptor isoforms....