demonstrate opposing roles for 5-HT2C receptors in the effects of SSRIs on motor function and affective behavior, highlighting the potential benefits of 5-HT2C receptor antagonists for both reduction of motor side effects of SSRIs and augmentation of therapeutic antidepressant and anxiolytic effects.doi...
JJ-3-45, JJ-3-42, and JJ-5-34 reduced amphetamine-stimulated hyperlocomotion, restored amphetamine-disrupted prepulse inhibition, improved social behavior, and novel object recognition memory in NMDA receptor hypofunctioning NR1-knockdown mice, and were essentially devoid of catalepsy. However, ...
The 5-HT2C receptor is a type of receptor that is found in certain parts of the human brain, including the choroid plexus, prefrontal cortex, and limbic structures. It is a type of postsynaptic receptor that is associated with G-protein coupled receptors and has excitatory effects. Stimulation...
USA; 2Department of Psychiatry, Columbia University, New York, NY, USA Although it is well established that hallucinogens act as 5-HT2A and 5-HT2C receptor agonists, little is known about the relative contributions of 5-HT2A and 5-HT2C receptors to the acute behavioral effects of these drugs...
fasting blood concentration of lipid and blood plasma leptin.The-2548G/A polymorphism in promoter region of leptin gene and the -759C/T polymorphism in promoter region of 5-HT2C receptor gene are not associated with risperidone-induced weight gain,disorder of fasting blood concentration of lipid,...
The serotonin 5-HT2C receptor (5-HT2CR) is expressed in amygdala, a region involved in anxiety and fear responses and implicated in the pathogenesis of several psychiatric disorders such as acute anxiety and post traumatic stress disorder. In humans and
Relapse vulnerability in cocaine dependence is rooted in genetic and environmental determinants, and propelled by both impulsivity and the responsivity to cocaine-linked cues (‘cue reactivity’). The serotonin (5-hydroxytryptamine, 5-HT) 5-HT2C receptor
Also, to minimize possible kinetic effects of G-protein coupling to the receptor, the ligand was incubated with the receptor for 30 min prior to reading. Interestingly, the ISI isoform was the most efficient transducer, while the IGV isoform was the least (Figures 1C and S1; Table S1). ...
particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and part...
side effects reduction; 5-HT2C receptor agonists or partial agonists; 1-{7-[3,5-bis(trifluoromethyl)phenyl]-2,3-dihydro-1-benzofuran-2-yl}methanamine; mood disordersdoi:US7396857 B2or a pharmaceutically acceptable salt thereof, wherein each of R 1 , R 2 , R 3 , n, y, and Ar are ...