demonstrate opposing roles for 5-HT2C receptors in the effects of SSRIs on motor function and affective behavior, highlighting the potential benefits of 5-HT2C receptor antagonists for both reduction of motor side effects of SSRIs and augmentation of therapeutic antidepressant and anxiolytic effects.doi...
Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in mal schizophrenic patients. European Journal of Clinical Pharmacology 64, 477-482.Gunes A, Dahl M-L, Spina E, et al (2008) Further evidence for the association between 5-HT2C ...
JJ-3-45, JJ-3-42, and JJ-5-34 reduced amphetamine-stimulated hyperlocomotion, restored amphetamine-disrupted prepulse inhibition, improved social behavior, and novel object recognition memory in NMDA receptor hypofunctioning NR1-knockdown mice, and were essentially devoid of catalepsy. However, ...
The 5-HT2C receptor is a type of receptor that is found in certain parts of the human brain, including the choroid plexus, prefrontal cortex, and limbic structures. It is a type of postsynaptic receptor that is associated with G-protein coupled receptors and has excitatory effects. Stimulation...
However, there is a lack of focus on the effects of 5-HT2C receptor mutations in disease, such as cancer. To shed light on the function of a potential cancer-driving gene, it is important to illustrate the mutational frequency and their associated biological consequence (Arang and Gutkind, ...
Activation of 5-HT2C receptors reduces the locomotor and rewarding effects of nicotine. Psychopharmacology 157: 292–298. Herrick-Davis K, Grinde E, Niswender CM (1999). Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. J ...
FIGS. 1A-1G illustrate the effects of seven different compounds of the invention on food intake in food-deprived rats. DETAILED DESCRIPTION OF THE INVENTION The present invention relates to 5HT2C receptor agonist compounds, methods of modulating 5HT2C receptors by contacting the receptors with one ...
and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2Creceptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insip...
side effects reduction; 5-HT2C receptor agonists or partial agonists; 1-{7-[3,5-bis(trifluoromethyl)phenyl]-2,3-dihydro-1-benzofuran-2-yl}methanamine; mood disordersdoi:US7396857 B2or a pharmaceutically acceptable salt thereof, wherein each of R 1 , R 2 , R 3 , n, y, and Ar are ...
It is suspected that the non-selectivity of some ligands contributes to various adverse side effects such as hallucinations and cardiovascular complications. Therefore, there remains a need for 5-HT2c selective receptor ligands.Bishop et al., " New 5HT2C receptor agonists, " Expert Opin. Ther. ...