盐酸鲁拉西酮: 一种5-HT2A receptor拮抗剂、D2 receptor拮抗剂药物,由Sumitomo Pharma Co., Ltd. (Sumitomo Pharma Co., Ltd.)公司最早进行研发,目前全球最高研发状态为批准上市,作用机制: 5-HT2A receptor拮抗剂(5-羟色胺2A受体拮抗剂),D2 receptor拮抗剂(多巴胺D2受体
The 5-HT 2C receptor was one of the first receptors of the 5-HT family to be cloned; although full-length sequences were difficult to obtain, due to a complex exon-intron structure. The receptor was mapped to human chromosome Xq24. Given its similar pharmacological and transductional ...
2022年12月19日，贝勒医学院徐勇课题组与剑桥大学Sadaf Farooqi课题组合作在Nature Medicine上发表题为 Human loss-of-function variants in the Serotonin 2C receptor associated with obesity and maladaptive behavior 的研究论文，首次发现5-HT2CR参与调节人类的食欲、体重和行为。首先， 研究人员通过对2548名（46%...
英文名5-HT2A receptor agonist-2 5-HT2A receptor agonist-2生物活性 描述5-HT2A受体激动剂-2是一种高效的5-HT2受体激动剂。5-HT2A受体激动剂-2分别以1.7、0.58和0.50 nM的EC50值激发5-HT2A、5-HT2B和5-HT2C[1]。 相关类别 研究领域>>心血管疾病 ...
5-HT2 antagonist 1 是一种有效的 5-HT2 receptor 拮抗剂,同时对 α1 adrenoceptor 有微弱地抑制作用。 产品性质 图谱 目录: 名称 生物活性 物理化学性质 英文别名 返回顶部 5-HT2拮抗剂1名称 中文名5-HT2拮抗剂1 英文名5-HT2 antagonist 1
5-HT receptor subtypes listed:5-HT1A,5-HT1B,5-HT1D,5-HT1F,5-HT2,5-HT2A,5-HT2C,5-HT4,5-HT5A,5-HT6,5-HT7 [1]Recherches sur les diméthylaminopropyl-N phénothiazines substituées. Charpentier P, Gailliot P, Jacob R, et al. Comptes rendus de l’Académie des sciences (Paris)...
Ritanserin (R 55667) 是一种 5-HT2 受体拮抗剂。 产品性质 英文别名(English Synonym) Ritanserin 中文名称(Chinese Name) 利坦丝林; 利坦色林 靶点(Target) 5-HT2 receptor H1 receptor D2 receptor α1 receptor α2 receptor 通路(Pathway)
A variety of ligands binds to the serotonin 2A receptor (5-HT2A), including biogenic amines, synthetic hallucinogenic tryptamines, as well as the recreational drugs: psilocin, psilocybin, lysergic acid diethylamide (LSD), and the hallucinogens: 2,5-dimethoxy-4-iodoamphetamine (DOI) and 2,5-...
SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist: to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral ...
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