Role of Phosphoinositide Hydrolysis and Protein Kinase C Activation in 5HT2 Receptor Function in Smooth MuscleSerotonin (5-hydroxytryptamine; 5HT) has long been known to play a major role in smooth muscle functioning. In general, 5HT induces contraction of several smooth muscle groups including ...
Serotonin function and the mechanism of action of antidepressant treatment Arch Gen Psychiatry (1984) J.F.W. Deakin et al. 5HT receptor subtypes and depression Psychopharmacology (Berlin) (1986) D.P. Goldberg et al. Dimensions of neuroses seen in primary care settings Psychol Med (1987) There...
Evidence suggests that frontal 5HT2 receptor sensitivity may be increased in schizophrenia, and that they modulate motor responses in parallel with dopamine while 5HT1A receptors modulate sensory processes with noradrenaline (Deakin 1991). We speculated that impaired executive motor function and associated...
receptor;5HT 2A receptor;Chirp;Electricorgan discharge Introduction Serotoninisapowerfulmodulatorofsocialbehavior,includ- ingaggressionandreproductivebehavior.Serotoninreleaseand activityissexuallydimorphicinmanybrainregionsandis influenced by social experience (Carlsson and Carlsson, 1988; Matter et al., 1998; Sum...
5HT1B /5HT1D receptor antagonists having a biphenyl structure have also been described in the Application WO 96/19477. Those structures in no way suggest the compounds of the present invention. The Patent Application WO 95/07274 describes compounds used in the treatment of disorders of the ...
BACKGROUND: Desired serotonin 5HT2 receptor pharmacology for treatment of psychoses is 5HT2A antagonism and/or 5HT2C agonism. No selective 5HT2A antagonist has been approved for psychosis and the only approved 5HT2C agonist (...
Alterations in adolescent brain serotonin (5HT)_1A, 5HT_2A, and dopamine (D)_2 receptor systems in a nonhuman primate model of early life adversityPharmacologyStress and resilienceStress affects brain serotonin (5HT) and dopamine (DA) function, and the effectiveness of 5HT and DA to regulate ...
Abstract: The SHT-induced shape change (SHT-SC) of blood platelets, which had been suggested to reflect the SHTs receptor-mediated function of the central nervous system (CNS), was examined in patients with depression before or after antidepressant therapy. The degree of SHT-SC did not differ...
receptorplateletThe SHT-induced shape change (SHT-SC) of blood platelets, which had been suggested to reflect the SHTs receptor-mediated function of the central nervous system (CNS), was examined in patients with depression before or after antidepressant therapy. The degree of SHT-SC did not ...
doi:10.1016/S0268-9499(96)80246-3ELSEVIERFibrinolysis