Lewis, D. A.NEUROSCIENCE -OXFORD-Shelton RC, Sanders-Bush E, Manier DH, Lewis DA (2009) Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience 158:1406-1415....
While the formation of myelin by oligodendrocytes is critical for the function of the central nervous system, the molecular mechanism controlling oligodendrocyte differentiation remains largely unknown. Here we identify G protein-coupled receptor 37 (GPR37) as an inhibitor of late-stage oligodendrocyte di...
in both adult schistosome worms (Supplementary Fig.1) and schistosomules9, PZQ evoked a rapid paralysis counteracted by exogenous 5-HT. On the basis of these observations, we considered whether PZQ acts as a direct serotoninergic ligand to oppose 5-HT evoked G-protein-coupled receptor (GPCR...
In addition to the lack of co-localization, the 5-HT2A receptor-expressing cells were smaller and less numerous than the adjacent NOS neurons. We propose that 5-HT2A receptor-expressing cells are local inhibitory interneurons whose one function is to ensure the reciprocal patterns of activity in...
Monoamine oxidase is a protein that breaks down the brain chemicals serotonin, epinephrine, dopamine, and tyramine. By preventing these brain chemicals from breaking down, it keeps their levels high in your brain. Because they work on several different neurotransmitters at once, they can have ...
G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron 19: 687–695. Article CAS Google Scholar Mahar I, Bambico FR, Mechawar N, Nobrega JN (2014). Stress, serotonin, and hippocampal neurogenesis in ...
Under a Creative Commons license Open accessThe central nervous system of Drosophila melanogaster contains an α-bungarotoxin-binding protein with the properties expected of a nicotinic acetylcholine receptor. This protein was purified 5800-fold from membranes prepared from Drosophila heads. The protein was...
A B 薰 ,t批 : lI t×)R A3l A3l 叁茎 l: 羹叁 _-_鼻I {l (tRK2 ’__⋯ 一 ’-_ __-- ·__。 GRK2 receptor overlay GRK2 receptor ovcHay ■■■望 ■■■ ■■■拳■■■ ■■■耄 ■l■■ ■■■蓍 参■■■ FIG.1.CytoplasmictailofD0RisrequiredforGRK2binding,translocati...
The Gα<sub>12</sub> and Gα<sub>13</sub> subtypes together form the least studied group of heterotrimeric G proteins. G protein-coupled receptor 35 (GPR35) has been suggested to couple efficiently to Gα<sub>13</sub> but weakly to Gα<sub>12</sub>. Using combinations of cells ...
A particular case exhibited two SMARCB1 mutations: c.592C>T in exon 5, and c.782delG in exon 6. Among the affected individuals, epithelioid sarcomas were seen in young adults, mostly male, with a mean age of 41 years. In the distal extremities, seven tumors appeared, and six additional...