While the formation of myelin by oligodendrocytes is critical for the function of the central nervous system, the molecular mechanism controlling oligodendrocyte differentiation remains largely unknown. Here we identify G protein-coupled receptor 37 (GPR
The 5-HT1A receptor is a G protein coupled receptor (GPCR) that activates G proteins of the G伪i/o family. 5-HT1A receptors expressed in the raphe, hippoca... Q Wang,A Terauchi,CH Yee,... - 《Cellular Signalling》 被引量: 0发表: 2014年 Sphingosine-1-Phosphate Signaling via the EDG...
LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular functions of LC3 in RNA biology is very limited.
Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A Author links open overlay panelR.C. Shelton a c, E. Sanders-Bush b, D.H. Manier a c, D.A. Lewis b cShow more Share ...
ELEVATED 5-HT 2A RECEPTORS IN POSTMORTEM PREFRONTAL CORTEX IN MAJOR DEPRESSION IS ASSOCIATED WITH REDUCED ACTIVITY OF PROTEIN KINASE A R. C. SHELTON,a,c* E. SANDERS-BUSH,b D. H. MANIERa,cAND D. A. LEWISb,c aDepartment of Psychiatry, Vanderbilt University School of Medicine, 1500 21st ...
Lewis, D. A.NEUROSCIENCE -OXFORD-Shelton RC, Sanders-Bush E, Manier DH, Lewis DA (2009) Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience 158:1406-1415....
GEMSA was performed using 32P-labeled probes containing either putative Tcf-4-binding sites TRE1 or TRE2. GEMSA was performed in the presence of a GST fusion protein containing the Tcf-4 DNA-binding domain as indicated. Wild-type (wt) or mutant (mut) competitors corresponding to the Tcf-...
. Analysis of protein–protein interactions via STRING revealed additional genes linked to PI3K–AKT/Rho GTPase signalling, with the majority expressed in astrocytes (e.g.Pik3r1, Fgf1, Prkca, Bcl2, Gulp1)and oligodendrocytes (e.g.Prkcz, Igf1r, Ptpn11, Pip4k2a, Rhoj) which is to be ...
in both adult schistosome worms (Supplementary Fig.1) and schistosomules9, PZQ evoked a rapid paralysis counteracted by exogenous 5-HT. On the basis of these observations, we considered whether PZQ acts as a direct serotoninergic ligand to oppose 5-HT evoked G-protein-coupled receptor (GPCR...
To date, at least 14 different 5-HTR subtypes have been identified in mammals and are grouped into seven families (5-HT1-5-HT7)3. Among them, 5-HT1aR, a metabotropic G protein-coupled receptor widely distributed in the frontal cortex, septum, amygdala, hippocampus, and hypothalamus that ...