5-HT2C Receptor:4000 nM (IC50) α1 receptor:10 nM (IC50) D2 receptor:40 nM (IC50) 体外研究 5-HT1A调节剂1(化合物24)也显示5HT1B,5-HT2A和5-HT2C受体的亲和力,IC50分别为300±55nM,500±75nM和4000±440nM [1]。 体内研究 5-HT1A调节剂1(化合物24)在小鼠中对5HT2A受体亚型显示出明显...
[27] Kishi T, Meltzer HY, Matsuda Y, et al. Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis[J]. Psychol Med, 2014,44(11):2255-2269. DOI: 10.1017/...
这些数据充分说明5-HT1A受体拮抗剂通过激活CREB/BDNF通路，增强PSD-95、GAP-43、Syn表达，促进突触重塑，保护大鼠海马神经元细胞，从而改善七氟烷致老年认知功能障碍模型大鼠的学习记忆能力。参考文献：ZOU Jiarui, CHEN Keyan, ZHANG Zhen. Effects of the 5-HT1A receptor antagonist on synaptic plasticity in ...
F-15599 是一种 5-HT1A receptor 激动剂,Ki值为3.4 nM。 产品性质 英文别名 (English Synonym) F-15599 中文名称 (Chinese Name) / 靶点 (Target) 5-HT1A 通路 (Pathway) GPCR/G Protein CAS号 (CAS NO.) 635323-95-4 分子式 (Formula) C19H21ClF2N4O 分子量 (Molecular Weight) 394.85 ...
ZOU Jiarui, CHEN Keyan, ZHANG Zhen. Effects of the 5-HT1A receptor antagonist on synaptic plasticity in sevoflurane-induced cognitive dysfunction in aged rats and its mechanism[J]. Journal of China Medical University, 2024, 53(1): 60-66,74. 发布于 2024-01-20 10:41・IP 属地湖北...
Disclosed is a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof, which can act as a 5-HT1A receptor agonist (serotonin 1A agonist) and is useful as a therapeutic or prophylactic agent for a mood disorder such as anxiety disorder and depression, a psychotic...
Schreiber R, Newman-Tancredi A. Improving cognition in schizophrenia with antipsychotics that elicit neurogenesis through 5-HT 1A receptor activation[J]. Neurobiology of learning and memory, 2014, 110: 72-80. 学习与记忆神经生物学,关注神经和行为的可塑性,包括学习、记忆以及神经适应相关的方面,涵盖学习...
5-羟色胺受体1B抗体(5HT1B Receptor)价格:￥1680/支产品详情:科淼生物简介 温州科淼生物科技有限公司(Whenzhou KeMiao Biological Technology Co.,Ltd)是一家专业从事“产品研发生产,市场销... 纯度:1mg/ml% 包装规格:100ul 用途:仅供科研使用 用途:仅供科研使用 ...
5-HT1A receptor激动剂[+3] 在研机构 Accord Healthcare SLU[+11] 原研机构 Otsuka Holdings Co., Ltd. 在研适应症 自闭症谱系障碍[+11] 非在研适应症 急性精神分裂症[+16] 最高研发阶段批准上市 首次获批国家/地区 美国 首次获批日期2002-11-15 ...
图VLZ可促进Tg (itga2b: eGFP)转基因斑马鱼的血栓形成 文献：Zhou L, Ni C, Liao R, Tang X, Yi T, Ran M, Huang M, Liao R, Zhou X, Qin D, Wang L, Huang F, Xie X, Wan Y, Luo J, Wang Y, Wu J. Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of...