Nowadays, in situ hybridisation, in vitro autoradiography, and radioligand binding on the one hand, and electrophysiological, behavioural, and neuroendocrinological responses on the other hand, are tools that allow the analysis of direct corticosteroid effects upon 5-HT receptors. Among the dozen of ...
Melatonin receptors are also expressed in the liver, which suggests the relevant functions of this molecule in this organ. Indeed, there is evidence for the inhibitory effects of melatonin on hepatic cancer [109,110]. 3.1.3. Possible Interplay between Pineal and Extrapineal ...
Evidence is presented that implies that conserved aromatic and charged residues are essential for ligand binding to 5-HT2A receptors. Additionally, findings are reviewed that are consistent with the hypothesis that residues located in intracellular loops 2 and 3 (i2 and i3) mediate coupling to ...
ALK breakpoints are almost invariably located between exons 19 and 20 of ALK. Each translocation creates a fusion protein in which the ALK TK-domain at the 3 -end is connected with distinct proteins portion of different partners at the 5 -end of the fusion, capable of providing constitutive ...