The 5-HT2Areceptor is located onhuman chromosome13q14-q21, and comprises 471 amino acids in rat, mouse, and humans. It is widely distributed in peripheral and central tissues and corresponds to the former 5-HT2or D receptor. 5-HT2Areceptors mediate contractile responses in manyvascular smooth...
To engineer a series of biased agonists for interrogating the 5-HT2AR-coupled signaling pathways associated with psychedelic potential, a scaffold exhibiting some degree of selectivity for 5-HT2AR over other 5-HT receptors is required. Most psychedelics are not selective for 5-HT2AR, exhibiting ...
Regardless, long-term use of tricyclic anti-depressants can reduce the density of 5-HT2A receptors in the cortex1 (due to functional regulation of the receptor), and 5-HT2A agonists have recently been found to reduce brain network modularity in patients with severe depression.4...
参考文献 Xiuli Zhao et al, Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3, Molecular Psychiatry (2022). DOI: 10.1038/s41380-021-01390-w 大话精神编译,转载请联系编辑部。 投稿请联系微信:dahuajingshen 或邮箱:dahuajingshen...
(CollegeofLifeSciences,FujianNormalUniversity.KeyLaboratoryofDevelopmentalandNeurologicalBiologyofFujianProvince,Fuzhou350108)AbstractObjective:Toinvestigatetheexpressionofnitricoxidesynthaseinthespinalcordfollowingtheblockadeof5-HT2Areceptorsofinflammatorytissues.Methods:2%carrageenanwasinjectedsubcutaneouslyintoonehindpawof...
Overall, the present results suggest that 5-HT2A receptors play a detrimental role in long-term memory deficits mediated by an excess 5-HT in PFC.doi:10.1016/j.euroneuro.2015.04.006AnnaCastañéLucilaKargiemanPauCeladaAnalíaBortolozzi
These differences could also be attributed to just a few amino acid differences in the sequences of the two receptors15. Our results suggest that though there are differences in signaling between the rat and human receptors, these differences did not extend to cell–matrix adhesion, which was ...
参考文献 Xiuli Zhao et al, Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3, Molecular Psychiatry (2022). DOI: 10.1038/s41380-021-01390-w
求翻译:activity at 5-HT2A receptors是什么意思?待解决 悬赏分:1 - 离问题结束还有 activity at 5-HT2A receptors问题补充:匿名 2013-05-23 12:21:38 5-HT2A受体的活动 匿名 2013-05-23 12:23:18 活动在5-ht2a受体 匿名 2013-05-23 12:24:58 活动在5-HT2A感受器官 匿名 2013-05-23 12:26...
6,Meltzer CC,Smith G,Prince JC,et al.Reduced binding of [18F] altanserin to serotonin type 2A receptors in aging:persistence effect after partial volume correction.Brain Res,1998,813:167 7,Rosier A,Dupont P,Peuskens J,et al.Visualisation of loss of 5-HT2Areceptors with age in healthy us...